1 Overview

Data

Normalization

Model options

Network processing

cor/cov method: pearson

2 Load and normalize data

Data

Normalization

2.1 Load TCGA data

See prepare.tcga.survival.data function for how to configure parameters.

This uses data packages from obtained from ‘github:averissimo/tcga’ that contain FPKM expression levels.

prepare.tcga.survival.data('ov.data.2018.11.30',
                           'primary.solid.tumor',
                            normalization        = 'center',
                            log2.pre.normalize   = TRUE,
                            handle.duplicates    = 'keep_first',
                            coding.genes         = TRUE,
                            subtract.surv.column = '')

2.1.1 Summary of data

## [INFO]        Loaded data from TCGA: ov.data.2018.11.30
## [INFO]               type of tissue: primary.solid.tumor
## [INFO]   observations (individuals): 370 (226 event / 144 censored)
## [INFO]            variables (genes): 19856

2.1.2 Survival curve

2.2 Load degree data

Network processing

  • Degree calculation: string
  • Edge cutoff: 0
  • Unweighted edges

cor/cov method: pearson

  • only applies if network type is correlation/covariance

2.3 Preparing degree vector

  • Normalize degree between 0 and 1
  • Hub: heuristic( 1 - degree )
  • Orphan: heuristic( degree )
  • trans.fun is a double power to scale the values

see ?glmSparseNet::heuristicScale or ?glmSparseNet::hubHeuristic

# see ?glmSparseNet::heuristic.scale
trans.fun <- function(x) {
    heuristicScale(x) + 0.2
}

2.3.1 Genes with degree above 4000

ensembl_gene_id degree external_gene_name
ENSG00000150991 10394 UBC
ENSG00000170325 6346 PRDM10
ENSG00000100300 5797 TSPO
ENSG00000174775 5614 HRAS
ENSG00000142208 5573 AKT1
ENSG00000111640 5363 GAPDH
ENSG00000163631 5260 ALB
ENSG00000177606 4952 JUN
ENSG00000141510 4936 TP53
ENSG00000197122 4903 SRC
ENSG00000254647 4592 INS
ENSG00000112062 4187 MAPK14
ENSG00000170315 4114 UBB
ENSG00000170345 4010 FOS

2.3.2 Original degree frequency

Original

LOG10 Scale on X-axis

3 Model Inference

3.1 Train and test sets

## [INFO] Size of sets: (size/events)
##  * Train: 80.00% ::  295 /  180
##  *  Test: 20.00% ::   75 /  46
## [INFO] Number of variables per model:
Model BaseModel Alpha TargetVars nvars
Elastic Net Elastic Net 0.20 30 30
Hub Elastic Net 0.20 30 30
Orphan Elastic Net 0.20 30 32
Elastic Net Hub 0.20 55 60
Hub Hub 0.20 55 57
Orphan Hub 0.20 55 55
Elastic Net Orphan 0.20 110 114
Hub Orphan 0.20 110 110
Orphan Orphan 0.20 110 112 
## [INFO] note, selected variables could be slightly different from target, to have more accuracy increase nlambda in code

4 Results

4.1 Relative risk distribution

Calculated using the inferred models and the train/test datasets. The higher the better.

Test Set

Train Set

4.2 Kaplan-Meier Curves

4.2.1 Models on test sets

Elastic Net (base model: Elastic Net)

Test set

Training set

Hub (base model: Elastic Net)

Test set

Training set

Orphan (base model: Elastic Net)

Test set

Training set

Elastic Net (base model: Hub)

Test set

Training set

Hub (base model: Hub)

Test set

Training set

Orphan (base model: Hub)

Test set

Training set

Elastic Net (base model: Orphan)

Test set

Training set

Hub (base model: Orphan)

Test set

Training set

Orphan (base model: Orphan)

Test set

Training set

4.3 Summary Table

weighted penalization project tissue cutoff coding.genes alpha model nvars km.train km.test c.index.train c.index.test
FALSE string ov.data.2018.11.30 primary.solid.tumor 0 TRUE 0.20 Elastic Net 30 0 0.0109182 0.7261498 0.6223973
FALSE string ov.data.2018.11.30 primary.solid.tumor 0 TRUE 0.20 Hub 30 0 0.8863784 0.6845049 0.5801913
FALSE string ov.data.2018.11.30 primary.solid.tumor 0 TRUE 0.20 Orphan 32 0 0.2136438 0.7343580 0.6572876
FALSE string ov.data.2018.11.30 primary.solid.tumor 0 TRUE 0.20 Elastic Net 60 0 0.0128688 0.7736692 0.6184581
FALSE string ov.data.2018.11.30 primary.solid.tumor 0 TRUE 0.20 Hub 57 0 0.2738661 0.7244598 0.5700619
FALSE string ov.data.2018.11.30 primary.solid.tumor 0 TRUE 0.20 Orphan 55 0 0.2776017 0.7736692 0.6398424
FALSE string ov.data.2018.11.30 primary.solid.tumor 0 TRUE 0.20 Elastic Net 114 0 0.1075200 0.8143886 0.6207091
FALSE string ov.data.2018.11.30 primary.solid.tumor 0 TRUE 0.20 Hub 110 0 0.5031194 0.8166821 0.5638717
FALSE string ov.data.2018.11.30 primary.solid.tumor 0 TRUE 0.20 Orphan 112 0 0.1762223 0.8273046 0.6347777

4.4 Non-zero genes

4.4.1 Venn Diagram of selected genes

4.4.1.1 Overlap between models (with same target number of variables)

Base model: Elastic Net with Target Vars: 30 and Alpha: 0.20

Base model: Hub with Target Vars: 55 and Alpha: 0.20

Base model: Orphan with Target Vars: 110 and Alpha: 0.20

Table of genes in models

(not running at the moment)

5 5000 Runs

5.1 C-Index distribution

Test set

Summary of C-Index and Log-rank

metric model base.model target.vars alpha mean std median min
C-Index (Test set) Hub Elastic Net 30 0.20 0.552 0.043 0.552 0.392
C-Index (Test set) Hub Hub 55 0.20 0.560 0.043 0.560 0.408
C-Index (Test set) Hub Orphan 110 0.20 0.569 0.043 0.569 0.427
C-Index (Test set) Elastic Net Elastic Net 30 0.20 0.563 0.042 0.563 0.407
C-Index (Test set) Elastic Net Hub 55 0.20 0.575 0.043 0.575 0.422
C-Index (Test set) Elastic Net Orphan 110 0.20 0.583 0.042 0.584 0.43
C-Index (Test set) Orphan Elastic Net 30 0.20 0.584 0.042 0.585 0.428
C-Index (Test set) Orphan Hub 55 0.20 0.588 0.041 0.588 0.431
C-Index (Test set) Orphan Orphan 110 0.20 0.588 0.040 0.589 0.441
Log-rank (Test set) Hub Elastic Net 30 0.20 0.352 0.294 0.267 7.11e-06
Log-rank (Test set) Hub Hub 55 0.20 0.357 0.295 0.284 1.72e-05
Log-rank (Test set) Hub Orphan 110 0.20 0.343 0.290 0.267 8.53e-06
Log-rank (Test set) Elastic Net Elastic Net 30 0.20 0.317 0.285 0.230 2.81e-06
Log-rank (Test set) Elastic Net Hub 55 0.20 0.271 0.271 0.172 2.95e-06
Log-rank (Test set) Elastic Net Orphan 110 0.20 0.255 0.266 0.152 1.46e-06
Log-rank (Test set) Orphan Elastic Net 30 0.20 0.240 0.261 0.132 1.5e-06
Log-rank (Test set) Orphan Hub 55 0.20 0.228 0.254 0.124 2.09e-06
Log-rank (Test set) Orphan Orphan 110 0.20 0.243 0.260 0.138 1.92e-06

C-Index Distribution

Rank

Elastic Net vs Hub
base.model r.squared
Elastic Net with target nvars: 30 alpha: 0.20 0.1853789
Hub with target nvars: 55 alpha: 0.20 0.2614007
Orphan with target nvars: 110 alpha: 0.20 0.3294882

Elastic Net vs. Orphan
base.model r.squared
Elastic Net with target nvars: 30 alpha: 0.20 0.6484846
Hub with target nvars: 55 alpha: 0.20 0.7131041
Orphan with target nvars: 110 alpha: 0.20 0.7394333

Hub vs. Orphan
base.model r.squared
Elastic Net with target nvars: 30 alpha: 0.20 0.1387881
Hub with target nvars: 55 alpha: 0.20 0.2069649
Orphan with target nvars: 110 alpha: 0.20 0.2635022

Train set

Summary of C-Index and Log-rank

metric model base.model target.vars alpha mean std median min
C-Index (Train set) Hub Elastic Net 30 0.20 0.672 0.013 0.672 0.621
C-Index (Train set) Hub Hub 55 0.20 0.720 0.012 0.720 0.674
C-Index (Train set) Hub Orphan 110 0.20 0.795 0.011 0.795 0.755
C-Index (Train set) Elastic Net Elastic Net 30 0.20 0.717 0.015 0.717 0.664
C-Index (Train set) Elastic Net Hub 55 0.20 0.758 0.013 0.759 0.712
C-Index (Train set) Elastic Net Orphan 110 0.20 0.818 0.010 0.818 0.782
C-Index (Train set) Orphan Elastic Net 30 0.20 0.722 0.013 0.722 0.674
C-Index (Train set) Orphan Hub 55 0.20 0.762 0.012 0.762 0.717
C-Index (Train set) Orphan Orphan 110 0.20 0.824 0.010 0.824 0.784
Log-rank (Train set) Hub Elastic Net 30 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Hub Hub 55 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Hub Orphan 110 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Elastic Net Elastic Net 30 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Elastic Net Hub 55 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Elastic Net Orphan 110 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Orphan Elastic Net 30 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Orphan Hub 55 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Orphan Orphan 110 0.20 0.000 0.000 0.000 0

C-Index Distribution

C-Index Rank

5.2 Log-rank test on Kaplan-Meier models

5.2.1 Log-Rank distribution

Cumulative

Distribution of Log-rank test with groups separated by high and low risk groups

Distribution

Distribution of Log-rank test with groups separated by high and low risk groups

5.2.2 Log-Rank Rank

5.2.2.1 Elastic Net vs Hub

base.model r.squared
Elastic Net with target nvars: 30 alpha: 0.20 0.0242134
Hub with target nvars: 55 alpha: 0.20 0.0471353
Orphan with target nvars: 110 alpha: 0.20 0.0708327

5.2.2.2 Elastic Net vs. Orphan

base.model r.squared
Elastic Net with target nvars: 30 alpha: 0.20 0.2622927
Hub with target nvars: 55 alpha: 0.20 0.2959644
Orphan with target nvars: 110 alpha: 0.20 0.3088798

5.2.2.3 Hub vs. Orphan

base.model r.squared
Elastic Net with target nvars: 30 alpha: 0.20 0.0216374
Hub with target nvars: 55 alpha: 0.20 0.0387474
Orphan with target nvars: 110 alpha: 0.20 0.0437876

5.3 Consesus genes

5.3.1 Selected genes over all runs

Bar plots of frequencies

Overlap between variables selected

Base model: Elastic Net with Target Vars: 30 and Alpha: 0.20

Base model: Hub with Target Vars: 55 and Alpha: 0.20

Base model: Orphan with Target Vars: 110 and Alpha: 0.20

5.3.2 Selected genes in significant runs

i.e. with pvalue < 0.05 in Log-rank test using the test set.

Bar plots of frequencies

Overlap between variables selected

5.3.2.0.1 Base model Elastic Net with target nvars: 0.20 alpha: 30

5.3.2.0.2 Base model Hub with target nvars: 0.20 alpha: 55

5.3.2.0.3 Base model Orphan with target nvars: 0.20 alpha: 110

5.3.3 Genes in Significant runs

i.e. with pvalue < 0.05 in Log-rank test using the test set.

Top consensus 20 genes

Gene Overlap total
HLA-DOB 2 7577
CAAP1 2 7335
FCGBP 2 7324
CDSN 2 6275
BTLA 2 5887
MAGEB4 2 5043
CTXN2 2 4983
ST7L 2 4843
RNF175 2 4837
CCDC160 2 4831
C10orf53 2 4759
AL365214.2 2 4586
OR4F17 3 4573
TARM1 2 4572
AADAC 2 4562
GMCL2 2 4299
BTNL3 2 4264
FAM120B 2 4242
CXorf65 2 4220
PLA2G2D 2 4132

All Genes

HLA-DOB(7577), CAAP1(7335), FCGBP(7324), CDSN(6275), BTLA(5887), MAGEB4(5043), CTXN2(4983), ST7L(4843), RNF175(4837), CCDC160(4831), C10orf53(4759), AL365214.2(4586), OR4F17(4573), TARM1(4572), AADAC(4562), GMCL2(4299), BTNL3(4264), FAM120B(4242), CXorf65(4220), PLA2G2D(4132), ETNPPL(4094), OR2I1P(4082), SLC39A5(4040), RWDD2A(3955), UBD(3918), EPHA4(3848), P3R3URF-PIK3R3(3778), PRSS16(3732), TLL1(3632), CD40LG(3555), ACOT13(3427), STAC2(3425), FAM236D(3401), PATE1(3222), PLPPR3(2941), RPS6KA2(2925), UBB(2849), TYMSOS(2831), GMCL2(2813), ZNF429(2776), PATE4(2739), CELA3A(2734), ENSG00000274897(2710), ROPN1(2706), AADAC(2702), GCNT4(2692), CRYAA(2639), USP17L8(2618), SULT1A2(2599), IL2(2579), PI3(2552), DICER1-AS1(2545), AL807752.6(2483), FBXO16(2458), LRIF1(2440), FP565260.2(2436), TPM3(2430), KRTAP2-2(2423), OPALIN(2419), AKT1(2396), FCRLA(2391), NFKB1(2361), TNFAIP8L3(2323), KRTAP2-2(2244), TOMM20L(2230), CXCL11(2219), OR11H1(2213), DEFB113(2202), ACTRT2(2167), OSTCP1(2156), APOA5(2147), LINC01619(2136), OR4D10(2115), OR11H1(2100), LYPD6(2094), POTEE(2046), RHAG(2029), HDAC1(2026), POTEM(2019), FAM27E3(1966), PATE2(1948), ZFHX4(1922), AC005832.4(1869), FBXO9(1868), MYC(1868), LILRA2(1859), CRYAA(1838), ARHGEF38(1827), SCN1B(1812), TSPO(1795), SAYSD1(1765), MAPK8(1754), TP53(1718), AC005258.1(1706), ZNF702P(1696), COA8(1663), PAX5(1651), INSL5(1649), UCN2(1643), DNAH8(1637), OR5D18(1628), OR5D18(1619), GAPDH(1611), UBC(1605), RALA(1592), NYX(1579), HSP90AB1(1577), LINC02881(1574), URI1(1571), ALB(1553), SYT14(1519), OASL(1514), RHOA(1513), SLC22A2(1504), BFSP1(1501), NUGGC(1469), LRRC19(1465), AKT2(1461), LINC00337(1451), NYX(1445), EDDM3A(1443), OR9G1(1441), RASL10A(1436), SERPINA10(1402), LEMD1(1402), GPR27(1400), AL354761.1(1384), EGFR(1378), FRK(1377), RAB34(1371), PPP3CA(1358), TPGS2(1355), CTAGE6(1347), P2RY14(1343), FAM180B(1333), IGFLR1(1322), STARD6(1322), INSRR(1319), POMZP3(1316), RGS20(1303), KRAS(1302), NSG1(1294), RB1(1288), CDC42(1285), NPAP1(1259), WFDC12(1254), C3orf38(1254), FDCSP(1241), ANXA10(1223), FADS6(1222), SERTM2(1222), NUTM2F(1217), ITPRID1(1212), CYP11B1(1203), EPS8L3(1193), CETP(1191), LGR6(1190), HABP2(1187), BPIFB3(1186), MATK(1173), AP003419.1(1162), LCK(1152), CLDN34(1148), RAD51D(1135), PEX5L(1129), GLRX5(1119), MAPK1(1116), MAP3K7(1102), UBL4A(1100), IL24(1094), RAC3(1094), TBP(1094), OR4D10(1091), SRC(1091), GAS1(1086), NRAS(1086), C2orf88(1085), ISG15(1073), MANF(1069), TMIGD1(1065), PIK3CG(1062), CACNA1C(1050), CDK5(1047), EPHA7(1037), DHRS9(1035), OR8H3(1034), PCSK4(1022), UCN2(1021), GBP5(1021), AC099489.1(1019), HRAS(1015), PRDM10(996), ACLY(988), CXCL13(982), FOS(978), CRCP(972), EIF4E3(966), JAK2(955), POMZP3(949), APOE(947), MAPK15(942), MS4A1(941), DDX41(941), KRTCAP3(938), TCF15(935), UMPS(934), CACNA1C(922), ATP2C2(920), MYLK4(920), DAP(918), NUTM2E(908), JUN(904), GLYATL1B(903), C18orf21(897), CETP(894), TMEM254(885), IL27RA(884), DPPA3(881), GTF2H2(878), INMT-MINDY4(877), AC013470.2(874), BTN3A3(873), OR4F17(862), SLC22A2(859), UBL4A(856), FOXO1(841), MMP17(841), AKAP12(840), KRTAP10-8(838), SMR3A(834), CYREN(832), ELP3(831), LTA(830), ATP1A3(819), WDR91(803), PRR36(803), MARCHF9(802), RGPD1(802), MAPK3(799), HMGB3(791), TMEM181(790), PRSS2(784), RHOU(781), CLTCL1(778), GATA5(775), PCSK6(775), MNX1(768), UBC(766), DECR1(759), GTF2H2B(758), C10orf120(756), MIR9-1HG(754), KRTAP4-11(753), FOXD4L6(750), VEGFA(742), TRIM75P(740), ALB(737), C16orf82(735), CMBL(732), WARS1(729), MAPK3(725), KCNJ18(724), PTEN(722), HSPA1L(721), ARL14(719), PPM1G(714), AGFG1(714), RHOU(714), APOL4(712), NPIPB2(712), ELAVL1(710), CMC4(710), VN1R2(710), DECR1(708), CDY2A(704), MAP3K13(703), MAPK12(702), H4C9(698), CXCL9(698), OR4F15(694), ANKRD18B(693), RAP1A(685), NOL7(677), GRAMD4(673), GRIN2D(671), TEX48(671), ENSG00000274744(670), SIGLECL1(664), TEX261(662), RGPD6(661), RAC1(659), INS(659), ALOX12(658), HMCN2(658), SERPINA9(654), CWC15(653), GTF2H2(652), FP565260.1(651), FAU(651), OR2W1(650), KRT78(649), STAT1(647), RAMP1(640), OR1B1(639), U2AF1L5(636), PPP5D1(630), WASF2(629), ELOA3C(624), CXCL11(624), GPR27(622), TEC(621), DYRK1B(616), IGFBP7(613), MRS2(611), CALM1(611), FBXO27(606), TOMM5(604), TPMT(602), MBD2(600), OGN(596), PSMG4(594), PRRG1(592), SCP2D1-AS1(592), ARRDC2(588), HSP90AB1(587), RHOA(586), TMEFF2(585), RIPK4(582), SIGMAR1(581), UBL4B(581), CLPSL2(571), OR1N2(568), MAGEB3(567), CDK4(562), C6orf141(560), TMEM242(555), TGM4(554), GSK3B(554), GIMD1(553), POPDC2(551), FGF23(550), BCL2(548), PBLD(543), C11orf53(539), ABCA13(537), ITGA2(535), CNIH3(533), OR52B2(532), HSPA8(531), SPDYC(528), IFNA7(528), RNF144B(526), DIRAS2(526), RNF128(521), WFDC10A(521), SLC46A2(517), IGLL3P(517), HSP90AA1(516), MAPK14(512), EML2(506), AKT3(504), SHH(503), LINC02877(497), CCDC83(496), AP1S2(495), PYGB(490), PYGB(487), CASP2(484), AC068234.1(483), OAS2(482), PRKAG1(481), NUTM2A(481), RAC3(476), CXCR2(474), GLB1L3(468), HMBS(468), SLC7A11(466), FURIN(464), WFDC8(463), PRKAR1B(461), ALG8(460), C14orf177(459), MAGEA9B(459), NOTCH1(459), GPR37(457), CD79A(454), PMCHL1(452), SPATA45(452), UNC79(449), ISG20(449), SNRPD1(448), SMIM10(447), ANGPTL4(442), PDP1(442), NBPF10(441), PC(441), TTC28(439), GAD1(437), JCHAIN(435), CDK4(433), AL445989.1(432), OBP2A(431), OR5T1(426), MYB(424), TRPV4(421), MAP3K21(421), ZNF7(421), TMEM72(411), ACTA1(411), CCDC54(410), RAD51(410), LINC01556(407), ACSM1(405), C1QL4(405), RASD1(402), STX18(401), PSMA2(401), LYRM2(400), WASF4P(395), SNCA(392), EPHB2(392), GOLGA6D(388), CCDC102B(388), ISG20(385), GRM8(384), C2orf74(384), CDH22(382), AC036214.3(380), STK32B(376), C17orf67(376), EPHB2(373), MIA2(373), SULT4A1(373), ARV1(371), PCDHGA6(371), PRIM2(369), PPP2CB(369), CITED2(368), OR7A17(368), BFSP2(367), CDKL4(366), CDK3(362), LINC02868(360), MYPOP(359), TCP1(357), DIRAS1(354), PRKN(353), UBE2J1(351), PNMA8B(351), SIRT5(350), ASB2(349), OR5BS1P(347), APOL5(345), INSRR(341), BECN2(339), ZCCHC7(338), TXN(337), F8A1(336), TFRC(335), TSPAN9(330), CCDC28A(330), CATSPERG(329), RHOJ(329), CCR7(328), SLC22A2(328), GFI1B(327), SPDYE3(327), HSPA6(327), MEP1B(326), ZNF385B(326), PLCH1(326), SLC13A1(325), TRPV4(324), ATP2A3(323), ABCC2(321), TNS1(321), DMC1(321), SLC45A2(319), OPA3(318), C17orf100(318), NOTCH2NLA(314), BORCS5(313), SEZ6L(312), PRKG2(312), SLC7A11(312), OR2A42(311), NBPF19(311), CDK6(311), SPRY3(306), SOD2(306), PIGS(303), ZSCAN1(303), NBEAL1(302), CDKN1B(300), CYLC2(300), SEPTIN1(300), CDH1(299), PPP3CB(299), LRRC19(299), EMP1(297), TIMM23(297), LYVE1(296), KIAA2026(296), LMTK3(295), TTC32(294), NUCB2(293), UNC119(292), AC092143.1(292), CDK14(292), TCAIM(291), SEBOX(291), UGT1A6(290), RHOC(290), DMAC1(286), FRMD7(286), DIRAS2(285), DIO3(284), MROH2B(282), TMEM244(281), ZNF316(281), ACTR10(281), FBL(280), AC018755.2(280), GMPR(280), CSF1R(280), MAPK6(279), WDR25(277), RET(277), LRFN1(275), PPEF2(275), RANBP2(275), C1orf131(274), C9orf57(274), KIR2DP1(274), ZNF826P(271), IQANK1(266), KIAA0825(265), C11orf71(264), RASGRF1(263), SBK3(263), AC009163.3(263), KISS1(261), AC006486.1(261), MAJIN(260), C18orf32(260), NPY(259), SDF2L1(258), TUBB2A(258), WDFY2(257), RRAS2(257), SCTR(256), DGLUCY(256), OCIAD2(254), BATF2(253), GOLGA6L7(252), PACSIN3(251), EPB42(251), TMEM217(251), POTEI(251), YIPF3(249), RAB25(249), TCEA1(247), TEX13A(246), HSP90AA1(244), EEF1AKMT3(244), THSD7B(244), PRKCH(243), PTPN2(243), HDAC2(243), SLAMF7(242), CHRAC1(242), ARL14EPL(242), MTRNR2L13(242), RIT2(240), RXFP1(239), PCDHB13(239), TCF15(238), C6orf226(238), CBLIF(238), CPLX3(237), PHGR1(237), RPS6KA1(237), MGAM(236), AHDC1(235), GTF2F2(233), SGK1(232), ERVMER34-1(232), CCR7(231), SNRPA1(230), PIM3(226), AR(225), PNPLA5(224), TK2(223), SLC25A47(222), CDK16(222), PTPN2(222), GPAT2(220), SULT1A4(220), PLAAT5(218), TRIM27(218), CACNG1(217), C17orf77(217), RHOV(217), CH25H(216), VMA21(216), RABL2A(216), CXCL13(216), TRIB2(215), IER3IP1(214), KIF26B(214), MAPK13(213), ZC2HC1A(212), FZD3(211), KRT79(211), CCL19(211), IL18BP(210), SEC22B(210), PPARG(210), RND1(210), POTEJ(210), REN(208), C6orf141(208), AR(207), HGD(206), GJB7(206), ACTL10(205), GPR146(204), LINC01011(204), OR6S1(203), FZD3(203), OR13H1(202), ZBTB14(202), CDK8(201), HOXB2(200), MALT1(198), PCSK5(197), AL109827.1(197), SELENOH(196), TCP1(196), ACTR1A(196), LGALS2(195), TXLNGY(194), EPHA1(194), GLI1(192), GOLGA8DP(192), GATD3B(192), IFNA5(191), DAGLB(191), WFDC1(190), IL6(189), ICOS(189), ZNF239(189), FBXO4(188), POLD2(188), SSBP1(187), DIRAS1(187), SLC25A52(186), OR6T1(186), ERBB4(186), WNT5B(185), LINC02218(185), SHH(185), OTUB2(184), CHAD(183), MDGA2(183), SUSD5(183), SVIP(183), RAD23B(183), TEX51(182), UTY(182), AC004080.3(182), RTL9(181), CD3G(179), RAD51D(178), RGPD8(177), RAP1B(177), MRPS11(177), AC011530.1(176), GATA5(176), CST11(175), SCRG1(175), C11orf94(174), MATK(174), DPYSL4(174), DMC1(173), PRDX5(173), RPS6KA3(173), GNAI3(172), FASTKD3(172), PADI3(172), CCT5(171), AC099811.2(171), CHI3L2(170), BHMT2(170), LURAP1L(170), MAP3K4(168), DNAJA1(167), ACTA2(167), ZBP1(166), TMEM45B(166), SIGLECL1(166), CAT(166), KLF5(165), TESK1(165), OAZ3(164), FAIM(164), GDPGP1(164), ARHGAP23(164), OR52B2(163), CT45A10(163), GCSAM(162), LYZL6(162), NUMBL(162), SGK1(162), TNFSF11(161), WFDC5(161), PRKN(161), GNAS(160), GON7(160), CCL19(160), SPINK13(160), TXK(160), CDK2(160), ATRAID(159), IGSF5(159), ZNF79(159), GPM6B(158), SLITRK3(158), EXOC6B(158), FGFR1(158), INSC(157), C8orf49(157), PRSS41(156), ODF4(155), CCT4(155), MAPK4(155), BPIFB2(154), SHISAL1(153), ASB2(153), STAT4(152), CATSPER4(151), TSPYL1(151), GRIN2D(151), DIRAS3(151), RTL8A(150), ANK3(149), TNS4(148), HDAC4(148), DERL2(148), PYY(147), CADPS(147), HDHD2(147), ABCA13(147), ZYG11A(147), DYTN(147), SLC13A1(147), PKN1(147), PCNA(147), IFI27L2(146), LEFTY1(146), PRKACA(145), HSPA1L(145), IGF1(144), ZCRB1(143), CYP2R1(143), PYY(142), IFNB1(142), CCL13(141), ACTRT1(141), FAXC(140), DACT3(140), NPIPB13(140), MICB(140), AC011452.1(140), MSL3(140), PRSS1(140), TM4SF4(139), GPR137(139), CCND1(139), ACTL8(139), DYM(137), NIPAL1(137), MRS2(137), MRAP2(136), RASL10A(136), OR4C11(135), MYL2(135), SNRPA1(135), RASL12(135), ZNF320(134), PCDHA5(134), TRIM38(134), CBWD5(133), PAK1(133), KIAA1328(133), KCTD15(133), ADGRG5(133), DTWD2(133), RAP1A(133), EFCAB13(133), PPARA(133), SOX2(132), HSFX1(131), MAP3K8(131), ARL6IP5(130), CRCP(130), TENM3(129), NCS1(129), NARS2(128), CASQ1(128), FOLH1B(127), DENND2D(127), FAM104B(126), KCNT1(125), PCDHB1(125), INSYN2B(125), RNASEK(125), MAP2K1(125), MVK(124), FILIP1(124), NCCRP1(124), SGK2(124), DCAF10(123), ORMDL1(123), ZNF750(123), RAB6D(123), FAM200B(123), SSX4(123), RSPO4(122), FAM83B(122), ANGPT2(122), GABARAPL1(121), PPP1R36(121), ZNF714(121), FBXO30(120), ANGPTL4(119), SCN3B(118), SMAD2(118), UBE2J1(118), CAMK1G(117), C1orf74(117), GABRB1(117), CACNG3(116), PAGE1(116), LRRC27(116), DMTN(116), FOXD4L4(116), HBE1(116), CETN2(115), ZNF12(115), DOC2B(115), TBL1Y(114), DKK1(114), METTL21C(114), GRB7(114), OOSP2(114), SECISBP2L(113), IQCF2(112), BTNL2(112), ANKRD27(112), RNF186(111), NCR3(111), PCDHA11(111), PADI6(111), PIR(110), MIR1-1HG-AS1(110), CARD17(110), CNPPD1(109), CFI(109), C19orf81(109), OR6C3(109), PPP5D1(109), TTC7A(108), U2AF1(108), RAP2B(108), CCDC34(107), CD8B2(107), AC091551.1(107), STK40(107), IFT27(106), MYH1(106), PDCD2(106), ACTL7B(106), GART(106), CHRNB3(105), NCBP2L(105), ZFAND4(105), OR6T1(105), ESR2(104), FCRL3(104), KRT84(104), ESM1(104), ABL1(104), CCT7(104), ADGRG7(103), LMAN2(103), OR2T7(103), HINT2(103), FRG2B(102), HDAC9(102), FLT1(102), CREB3(101), ORC3(101), LY6D(101), LINC02873(101), LYG1(100), USP17L20(100), PCSK1(100), TRIM38(99), HMGN3(99), ANKRD62(99), ARL4C(99), IGSF23(99), LINC00479(99), LPAR2(99), REM1(99), HSPA2(99), GABRA3(98), NPB(98), CDK18(98), PPIL3(98), TRIM5(97), ZNF780A(97), UBE2F-SCLY(97), SMUG1(97), CHAD(97), MAGEB2(96), DPH6(96), MAT1A(96), DXO(96), TSSK1B(96), KIAA0100(95), HEPACAM2(95), HDAC11(94), MYEOV(94), RTL8B(93), C22orf42(92), TFRC(92), DCSTAMP(91), IER5L(90), CNIH3(90), SPINK1(90), FAM236D(90), S1PR4(89), PRR3(89), PPP3CC(89), BNC1(88), NLRP13(88), DUOX1(88), KRTAP21-1(88), OTC(87), COL19A1(87), LYRM1(87), WASHC4(87), FLG2(87), ARSH(87), RPS4Y2(87), MNX1(87), CCT2(87), ECI2(87), NEK3(86), B3GALT1(86), CCDC61(85), GBP4(85), HMGN5(85), SPATA31A1(85), AC005726.1(85), EPHA7(85), GBP5(85), OR13H1(84), PWP2(84), JAK1(84), RBAKDN(83), KAT2B(83), CH25H(83), RIT1(83), YES1(83), CXCR2(83), KIR3DX1(82), CYP4F22(82), HERC1(81), DDX59(81), APCDD1(81), PAPOLA(81), TRIM77(81), OR51I2(80), CPS1(80), MATN2(80), C1orf105(80), TRIM49D1(80), CREB3L3(80), MAP3K21(80), ARSD(79), MYO5B(79), PLAAT2(78), ELAC1(78), AMBN(78), KRTAP9-9(78), SERPINB5(78), AMPD1(78), PDGFRA(78), EXOC6B(78), UEVLD(78), TTC38(77), LRRC17(77), C1orf35(77), TCTA(77), HTRA4(77), EFNA5(77), EID3(77), AC010547.4(77), YWHAZ(77), TTC8(76), PRKG1(76), ZNF239(76), TXNL1(75), HBZ(75), JUNB(75), MXRA7(75), CDK17(75), CA2(75), BTN3A1(74), IFT74(74), C4BPA(74), ZNF780B(74), IFI27L1(74), C14orf178(74), ARID1B(74), ACTB(74), ARPC5(74), FRMPD1(73), FGF4(73), AKIRIN2(73), MICU2(73), DEFB108B(73), BCL2L15(73), TMEM207(73), AP001458.2(73), SERPINA2(73), EXOSC3(73), EVL(73), MPHOSPH6(72), IP6K3(72), DSCR10(72), RAP2A(72), GSKIP(71), MTARC1(71), ATP6V1G2(71), TEX22(71), JUP(71), TBC1D7(70), ANO5(70), PPP2CA(70), ERBB2(70), NEDD8-MDP1(69), PAGE5(69), C9orf106(69), LYNX1(69), SRL(69), HSPD1(69), ACTBL2(69), SUMO2(69), P2RX1(68), C22orf24(68), MMD2(68), D2HGDH(68), TMEM271(68), EPB41L2(67), RCN2(67), KLK4(67), SHISA3(67), FGF23(67), GGCX(66), UBE2Q2(66), EN1(66), PRSS48(66), PIK3CA(66), SFTA2(66), SDF2(65), MRPL55(65), DNASE1L3(65), LINC01620(65), LRRC28(65), ZNF8-ERVK3-1(65), PRKG2(65), UNC5C(64), TAS2R46(64), RPEL1(64), TGFB1(64), DNAJC4(64), ARL5C(64), DCTN1(64), GLYATL1B(64), UXS1(63), DCUN1D5(63), C22orf42(63), FCER2(62), IFT172(62), H2BC9(62), SOX6(62), MKKS(62), LINC02868(62), ITPKC(61), MFSD11(61), HPDL(61), CHURC1(61), H3C8(61), IQCA1L(61), GFUS(61), AKAP11(60), NEBL(60), ARPIN(60), CHKA(60), STK32B(60), OR4K5(60), TAS2R8(59), TESPA1(59), INTS6L(59), LINC00314(59), HYI(59), GDF5-AS1(59), MEF2A(59), CALB1(59), SLC2A11(59), CYBRD1(58), TES(58), GPR171(58), ADH1B(58), AMMECR1(57), KCTD4(57), KRT8P41(57), XPO1(57), LYVE1(57), UBQLN1(57), MTOR(57), SYT10(56), DCTN3(56), PI4KAP2(56), OR6V1(56), RSPO4(56), MYH14(56), ATPSCKMT(55), DNAJB7(55), TAT(55), COX20(55), UBXN2A(55), IRS2(55), DACT3(55), PGLYRP1(54), LHX2(54), ZC2HC1B(54), ADCK2(54), MIGA2(54), NGRN(54), LINGO3(54), SLC4A8(54), MIB1(54), ACSS3(54), EIF4E3(54), FOXG1(54), TFB2M(53), MAP1A(53), RFPL4B(53), AC007998.2(53), TBC1D22A(53), SIRT5(53), MIF(53), CUX1(53), PMVK(52), MIOS(52), PPP1R14B(52), SYNDIG1L(52), LRIT3(52), GNAO1(52), MCM3(52), OR1L1(52), PRORP(51), SPOCK2(51), VPREB3(51), VSTM2L(51), TM4SF19(51), PAXX(51), C1QL3(51), GSDMA(51), MGAT4C(51), C2orf16(51), STMP1(51), FBXO17(51), TYW1B(51), TRPV5(51), RNF128(51), ACTG1(51), MPHOSPH8(51), FAM234B(50), COX8C(50), RIPPLY2(50), NBPF14(50), TNFRSF17(50), EPB41L2(50), ELAC1(50), RALB(50), CALML5(50), EXT1(50), GAL(49), NBN(49), C6orf223(49), PRAMEF11(49), GTF2H5(49), UBE2NL(49), MAP2K2(49), CREB3L3(48), ARF1(48), SDHAF4(48), SERPINB8(48), KRCC1(48), TUBA8(48), APOC2(48), AC022826.2(48), PIK3C3(48), ATP1A3(48), CPT1A(48), TGM7(47), LIPC(47), METTL23(47), SPANXA2(47), PDLIM1(47), YWHAE(47), FZD10(47), WDFY2(47), C1orf74(47), ERN1(47), SPANXD(47), IL32(46), MAMLD1(46), SLC37A4(46), RYK(46), PLEKHF1(46), AC073610.2(46), PDGFRB(46), IL6(46), LRRK1(46), STMP1(46), KIF26A(45), LYPD5(45), BTN3A2(45), IQCJ(45), MIR600HG(45), RHOBTB2(45), FOXP3(45), BCCIP(45), CDK15(45), EPHA1(45), LATS2(45), ACTL7A(45), HEPACAM2(45), HSPD1(44), PAQR8(44), PKN2(44), DDX24(44), RAB11A(44), ASL(44), MGAM(44), FP565260.4(44), TSPAN6(43), ST7(43), TTC23(43), NICN1(43), ST8SIA6(43), FAM228A(43), PCSK5(43), IFT57(43), KYAT1(43), NDRG3(42), GGT2(42), IGLON5(42), ST6GALNAC6(42), ZER1(42), MZB1(42), OBP2B(42), DAB1(42), AHNAK2(42), IQCF6(42), AC110275.1(42), AC104109.3(42), TFAM(42), PCSK7(42), ZNF320(42), STS(41), NPRL2(41), SMYD1(41), TNFRSF8(41), MYH2(41), DOCK11(41), GALP(41), KRTAP5-8(41), TRABD2B(41), KMT2B(41), PDK4(41), PKM(41), ARHGDIG(41), FBXO6(40), MAL2(40), PGLYRP4(40), HTR1A(40), KRTDAP(40), DCAF12(40), RAMACL(40), CD38(40), PPP5C(40), TBPL1(40), CASP2(40), GIMAP7(40), GPR179(40), STRN4(39), AAK1(39), SPATA1(39), CALML3(39), PRAMEF27(39), DNAJA1(39), ZNF574(39), LMO4(39), MARCHF3(39), EHMT2(39), SLC6A12(38), TFCP2L1(38), GNAI1(38), BLOC1S1(38), CCDC25(38), FAM102A(38), RARG(38), RIMBP3C(38), KRTAP5-11(38), KRTAP10-10(38), KRTAP9-1(38), AC244197.3(38), DCT(38), WWP1(38), KIT(38), GON7(38), MALT1(38), PTP4A3(38), LY86-AS1(38), RDH14(38), GRIK5(37), KIF2B(37), SHQ1(37), WTAP(37), SORCS2(37), IL1RAPL2(37), KRTAP5-3(37), NPIPA2(37), C2orf15(37), GSK3A(37), GALK2(37), STOML2(37), UGT1A6(37), ZNF354A(37), CDK1(37), GOLGA8M(37), ELANE(37), AL355916.3(37), ENSG00000241978(36), LRRC41(36), ADGRB3(36), SLC22A3(36), SHISA5(36), ARL6IP6(36), OR4E1(36), KIAA0100(36), ESR1(36), PDE10A(36), MEP1A(36), SYNCRIP(36), NXF3(36), PRKCA(36), LRRC28(36), ANKRD45(36), MITF(36), TIFAB(36), UBXN8(35), MGP(35), ANXA3(35), GABRA2(35), SPACA5(35), FAM222B(35), LCE5A(35), ZDHHC17(35), C9orf92(35), FOXL2NB(35), AATBC(35), UBE2L5(35), AC018523.2(35), MVK(35), OAS3(35), LRCH2(35), HMCN2(35), DNASE1L3(35), OR5BS1P(35), AL445989.1(35), TAZ(34), RETN(34), YDJC(34), CBWD1(34), GSTK1(34), NTF4(34), TPTE(34), NTN1(34), RASD2(34), RPL3L(34), OR4F15(34), LPA(34), TDP1(33), PCDHB6(33), ZNF670-ZNF695(33), BAAT(33), LOXL4(33), ZFYVE28(33), UCN3(33), CLDN4(33), TCF15(33), NARS2(33), OR4D1(33), LEP(33), NDUFV2(33), KIR2DP1(33), AC068533.4(33), LINC01101(33), ZNF76(32), PCDHB10(32), APOBEC3F(32), FCRL2(32), SOHLH1(32), MAGEF1(32), NKAIN3(32), TEX38(32), KRTAP27-1(32), CLLU1(32), USP28(32), PDE4D(32), SLAMF1(32), USP43(32), ANKRD20A19P(32), PPTC7(32), ZNF487(32), SDR39U1(31), STK3(31), MAX(31), GALNT8(31), COG3(31), SLC44A5(31), HGSNAT(31), STAP2(31), C17orf99(31), PLAC9(31), TAF13(31), SMIM35(31), ERBB3(31), ALDOC(31), MRPL3(31), GBP4(31), OR13H1(31), ELOA3C(31), ANKRD13A(30), EMC9(30), RARS1(30), ANO7(30), UBTD1(30), HMGB4(30), SLIT1(30), KRTAP12-1(30), ACTC1(30), PBK(30), GRM8(30), EFNA5(30), C9orf129(30), APMAP(29), RBM45(29), PRY(29), ZHX3(29), AC104389.5(29), APOBEC3C(29), TBC1D3(29), GAPDHS(29), AMBP(29), SUPT6H(29), SET(29), RCL1(29), YWHAB(29), SEMA6B(29), KMT5A(29), NT5C3A(28), GGPS1(28), RADIL(28), ANKS6(28), KRTAP5-1(28), NPIPA8(28), ADH1C(28), ALG1L2(28), PPIAL4F(28), WNT5B(28), C22orf24(28), SCP2D1-AS1(28), ZNF692(28), RXFP1(28), PFN4(28), HIBCH(28), LINC02218(28), AC010542.3(28), NEXMIF(27), LAMP3(27), CEP89(27), CGA(27), EDNRB(27), ZNF92(27), KCTD14(27), TMEM67(27), RNF214(27), KRT16(27), KRTAP12-3(27), ENSG00000241978(27), ABCC8(27), RPS6KA6(27), OGG1(27), TMIGD3(27), AK7(27), CCT5(27), ZSCAN1(27), KLHDC9(27), DNAJB7(27), BDNF(27), C20orf204(27), POTEH(27), ARSH(27), OR6B1(27), TEX51(27), OR52B2(27), MYDGF(26), CSPG5(26), RNF217(26), PPP4R2(26), MTMR14(26), IRF2BP1(26), RLN3(26), AQP11(26), C15orf32(26), RINL(26), LINC02860(26), APOC4-APOC2(26), RHEX(26), ACE2(26), TEC(26), TMEM14B(26), WDTC1(26), USP18(26), C5orf60(26), SCRT1(26), MCUR1(25), MRPS24(25), CERK(25), PLGLB2(25), CANX(25), SLC38A4(25), TMEM19(25), GALNT10(25), ZDBF2(25), FP565260.6(25), CACNA1G(25), TXNL1(25), EP300(25), SMR3A(25), STK25(25), TNFSF11(25), TOP2A(25), USP26(25), GABARAPL1(25), GOLGA6D(25), VSIG4(25), COX6A2(25), BRPF1(25), NRN1L(25), ZSCAN26(25), KEL(25), RAB6D(25), LYZL6(25), TAF1B(24), MIF4GD(24), FOXA2(24), C19orf12(24), PI16(24), C6orf120(24), MRPL40(24), HLA-F(24), SAPCD1(24), H2BS1(24), ELP1(24), ACACB(24), ZC3H14(24), ASH1L(24), SEC14L4(24), WT1(24), C16orf54(24), MYO18A(24), ERICH2(24), ZNF271P(24), F8A1(24), PLEKHH3(23), CAPN6(23), RIPOR2(23), RARRES1(23), IDUA(23), CA1(23), CD101(23), TCN1(23), PAFAH1B2(23), SLC22A12(23), AL359736.1(23), SCTR(23), HBQ1(23), TRIB3(23), CLTA(23), RAF1(23), ELP3(23), STC1(23), SHISA5(23), IGF2(23), HSPA4(23), FAM174A(23), RAD51B(23), PRORY(23), C1QTNF9B(23), OR2A42(23), GSG1L2(23), PGAM4(23), HNF1B(23), PADI6(23), PEX3(22), FNDC8(22), MISP3(22), LINC01600(22), WEE1(22), PPIP5K1(22), NAIF1(22), PLA2G2E(22), GAGE2A(22), POLDIP3(22), BCL2L11(22), CDK19(22), U2AF1(22), COL26A1(22), MOS(22), P4HB(22), MYL4(22), AL445985.1(22), WDR62(21), KIZ(21), ELK3(21), ZNF391(21), ART5(21), PAPPA(21), LRRC66(21), KLF5(21), SNAI1(21), CALM2(21), RRAD(21), TERB2(21), GAK(21), ZFP36L1(21), ZFP91-CNTF(21), AC010132.3(21), RGS17(20), CHRNA10(20), MAP1S(20), MRPL35(20), BPHL(20), G6PC2(20), STXBP6(20), GOLGA6L2(20), ODAPH(20), B3GNT8(20), OR4F6(20), SPOCK3(20), KLF14(20), CTAGE15(20), FYN(20), ATP2C2(20), ZC3H15(20), JAK3(20), PNPLA7(20), KYAT3(20), ACTR2(20), HTRA4(20), MLLT3(20), EXOSC4(20), MYBL1(20), ZNF536(20), TRPC5OS(20), GOLGA2P7(20), GIMD1(20), C8orf88(20), OR4E1(20), STRAP(19), SMU1(19), IDO1(19), AEBP2(19), PDIA4(19), SAMD8(19), FMC1(19), HSPB3(19), HES7(19), PPP1R2(19), TMSB4XP8(19), GTF2IRD2(19), LINC00336(19), OR5B21(19), CTAGE8(19), AC015813.2(19), FGR(19), OAS1(19), POLI(19), GRB10(19), HIF3A(19), DCLK1(19), RITA1(19), VEGFC(19), NMT2(19), PPEF2(19), ACTG2(19), DRGX(19), CMC4(19), GDPGP1(19), UST(18), CSTL1(18), LGALS12(18), SCEL(18), F13B(18), C1orf115(18), ZNF610(18), PSME3IP1(18), TSPEAR(18), LRRC14B(18), TMEM17(18), EPHA8(18), TNS1(18), GGT1(18), ARHGEF7(18), P2RX1(18), C6orf62(18), DAP(18), ZC2HC1B(18), APOBEC3A(18), ERN2(18), TESPA1(18), PCSK6(18), TERT(18), ACSM1(18), OR7D4(18), HTR1D(18), ACTL9(18), ZNF93(18), AMTN(18), LRRK2(18), SERPINB5(18), TRABD2B(18), P2RX6(17), APOBEC3A(17), XPO4(17), CLDN10(17), PDCL(17), FITM1(17), TMEM91(17), HIF1AN(17), C16orf78(17), ENHO(17), WFIKKN2(17), SCN4B(17), ACOT1(17), DLEU7(17), RNF133(17), CENPS-CORT(17), PAGE1(17), GLI2(17), BCKDHB(17), USP10(17), PHOX2B(17), GLI1(17), NANOG(17), TARS1(17), AAK1(17), TEK(17), PLAAT2(17), METTL21C(17), BHMT(17), PTPRD(17), PDIA4(17), MED19(17), CTNNB1(17), B3GALT1(17), OR10H5(17), ABCA13(17), OR10D3(17), C18orf63(17), LINC02860(17), RNF225(17), TBC1D3C(17), POLR3B(16), ZNF839(16), CELF4(16), PLGRKT(16), DNTT(16), MED20(16), SHFL(16), GALNT15(16), ZSWIM4(16), ZIC1(16), COX7B2(16), TTC36(16), ASPDH(16), OR2J3(16), NPEPL1(16), SMIM27(16), RHPN1-AS1(16), TAS2R31(16), SPDYE6(16), NUB1(16), IGF1(16), DNAJC25(16), GABRP(16), CAB39L(16), TBCC(16), HSPA12B(16), YWHAQ(16), ESCO1(16), BCL2L1(16), LINC00324(16), NLRP11(16), ACTRT3(16), OR7A17(16), ZNF485(16), LGALS17A(16), AC013470.2(16), KCNJ18(16), SSX4(16), SOCS7(16), TYR(15), TECTB(15), PLXDC2(15), SLAIN1(15), TRPT1(15), NRGN(15), CCDC107(15), RSKR(15), SOSTDC1(15), PDE7B(15), COL24A1(15), PAIP1(15), COL6A6(15), ERFL(15), STK17B(15), HAL(15), SERPINA4(15), ECH1(15), MEOX2(15), TYRP1(15), RND2(15), TUBA4A(15), FOXA1(15), JUND(15), DUOXA1(15), ARL11(15), MRAS(15), ABCG1(15), ZNF12(15), OR1L6(15), TMEM217(15), LRFN4(15), ZHX3(15), EPHB3(15), HOXB4(15), SMIM10(15), HSF1(15), BCL2L15(15), WDR5(15), TMEM244(15), LRRC37A11P(15), NTF4(15), PCDHA11(15), TRIM75P(15), EID3(15), CCL18(15), TRAF3IP2(14), FAM107B(14), SIDT1(14), MAGED2(14), RNF32(14), TECTA(14), TAS2R9(14), AVPR2(14), FAM189A2(14), HTR3B(14), MPZL2(14), TSPAN7(14), KLHDC8A(14), SLC38A8(14), FOXI1(14), MS4A10(14), FOXR1(14), DPM3(14), GATA2(14), ENPP7(14), SERHL2(14), CTBP1-DT(14), C10orf62(14), MCCD1(14), HSBP1(14), PATE3(14), ZNF487(14), AP002373.1(14), AGAP7P(14), FGFR3(14), HACE1(14), CERK(14), SARS2(14), BAG2(14), ELK1(14), TPH1(14), AFDN(14), VSTM2L(14), LGR6(14), GRB7(14), DOCK11(14), GPAT4(14), GJB7(14), SYK(14), HACD1(14), ATP23(14), NCBP2L(14), OR1N2(14), ARL14(14), MRPL14(14), EHMT1(14), TCAF1(14), PNMA5(14), ANKRD18B(14), EPOP(14), ACSM3(13), HSCB(13), REPS1(13), MMP27(13), ZIM3(13), CCDC3(13), SAXO1(13), MEIOB(13), KCNV2(13), GDNF(13), IL12A(13), SHARPIN(13), C12orf60(13), LRTOMT(13), RGPD2(13), ZNF34(13), AMZ2(13), ZFP2(13), AC087632.2(13), ACSM3(13), SNRPD3(13), HSD17B1(13), GNB3(13), CNTN3(13), RAB14(13), TBC1D15(13), GHSR(13), SPATA1(13), HTR2B(13), NIBAN2(13), BPHL(13), MFAP1(13), TXNL4A(13), SH3KBP1(13), ADGRL3(13), BORCS7(13), BATF2(13), CX3CR1(13), LRRC45(13), GOLGA8DP(13), RHOG(13), TMIGD1(13), AP2A1(13), TSEN15(13), VPS16(13), C16orf82(13), AC068234.1(13), ACACA(13), ENSG00000181013(12), FUT8(12), SIRT2(12), CPNE3(12), CORO7-PAM16(12), MORN1(12), NAAA(12), HIKESHI(12), CLDN17(12), GPS1(12), FAM110C(12), USP17L4(12), EBLN2(12), AL110118.1(12), ERVV-1(12), TOMM34(12), HSPA5(12), ABCB1(12), DICER1(12), CNPPD1(12), FASTKD3(12), ACTL6A(12), BRD4(12), WNT9A(12), UBALD1(12), GRIP1(12), REL(12), NOS3(12), LLCFC1(12), EPB42(12), LPO(12), CALB2(12), SIGLECL1(12), OR2T29(12), TCEA1(12), CLDN4(12), BECN2(12), HLA-F(12), OR2H2(12), CELA3B(12), LINGO3(12), AC055876.5(12), NEFL(12), RBFA(11), GPR63(11), PDE11A(11), DPP9(11), GLB1L2(11), TGIF2LX(11), PIEZO2(11), GBP2(11), COA6(11), TPST1(11), CCDC144A(11), MUCL1(11), TNK1(11), TMEM139(11), LCN10(11), VEPH1(11), FKBPL(11), TMEM256-PLSCR3(11), PRKCH(11), FLT4(11), ATP2A3(11), MYDGF(11), NFX1(11), GATA3(11), DKK1(11), PIKFYVE(11), UXS1(11), ANKRD60(11), ZBP1(11), C1QL1(11), FCRL2(11), TCEAL4(11), GGT2(11), ORC3(11), COG3(11), GUCD1(11), IGLON5(11), KDM6A(11), CCDC82(11), TMEM251(11), PCYT1A(11), TAL1(11), BMP10(11), PRRT3(11), UBTD1(11), HIF1AN(11), OR51Q1(11), INSR(11), PRKCE(11), SHANK2-AS3(11), EIF1AX(11), UNC5C(11), WWOX(11), BTN3A2(11), VSTM1(11), FAM180A(11), ZNF780A(11), MUC2(11), SYT15(11), PFDN6(11), MICB(11), TMA7(11), GOLGA8N(11), DNAJC25-GNG10(11), CT45A10(11), CEACAM7(10), PAX2(10), MYO9B(10), TSPAN13(10), FGFR1OP2(10), GADD45A(10), RSPH3(10), CAPN9(10), SH3GL1(10), SETBP1(10), ASZ1(10), LY6K(10), RBP7(10), PDCL2(10), SYNPO2L(10), URM1(10), OTUB1(10), INSM2(10), ARF4(10), CAVIN3(10), REP15(10), FAM133A(10), RBM11(10), CLDN24(10), TREML4(10), FAM111B(10), OR14A16(10), PRRT1(10), MUC5AC(10), CYP21A2(10), PCDHB16(10), CRY1(10), TBL1Y(10), RHOXF1(10), MAGT1(10), UBE2I(10), FBL(10), PAK1IP1(10), ALDH5A1(10), MAPKAPK3(10), EPX(10), CLCC1(10), EPS15L1(10), WDR74(10), TMTC1(10), GATA4(10), RHOB(10), SRPRB(10), CALM3(10), PRKCD(10), GPR146(10), KLK4(10), CABP2(10), ING2(10), TMEM223(10), HTR1A(10), C9orf106(10), PER1(10), OR2AP1(10), C4orf50(10), TMEM30B(10), OR4F5(10), OR51I2(10), IER5L(10), CCDC189(10), PCBP2(10), TAF13(10), H4-16(10), OR8G1(10), GAGE1(10), OR6V1(10), FTCDNL1(10), NACA2(10), AP002990.1(10), KLF14(10), AC104109.3(10), AC073610.2(10), H3C8(10), GAGE13(10), AC243547.3(10), NEDD4L(9), NAALAD2(9), CADPS2(9), TGFBR1(9), OCIAD1(9), ARMH3(9), FAM110A(9), CSH1(9), KIAA0319(9), TRPM2(9), PURB(9), AGBL3(9), CIZ1(9), SH2D6(9), XKR8(9), CPAMD8(9), C12orf50(9), TMEM223(9), ZNF395(9), SMIM9(9), SAMD13(9), AC093155.3(9), ENSG00000181013(9), MAD1L1(9), PSMB1(9), ZNF839(9), SNX1(9), ACTR6(9), FAM234B(9), FH(9), GATA1(9), NBN(9), UBXN8(9), DMAC2(9), MET(9), SPATA6L(9), NOP2(9), CMAS(9), ACTR1B(9), CCNI(9), RRAS(9), GAD1(9), DCAF15(9), RERG(9), RHOF(9), ARF1(9), MAL2(9), NAPRT(9), PAXX(9), LRRC27(9), THYN1(9), DMTN(9), TFB2M(9), PM20D1(9), MSX1(9), SVOP(9), SPATA24(9), KISS1(9), RPS6KB2(9), STAP2(9), NKAIN3(9), NCCRP1(9), INSYN2A(9), TSPYL1(9), TAT(9), NCR3(9), INSYN2B(9), CDPF1(9), FANCG(9), ERVMER34-1(9), TNF(9), PHGR1(9), DSCR10(9), MRPL20(9), AL136295.3(9), ENSG00000204683(8), CRLF1(8), MRC2(8), NFYC(8), CACNB1(8), JMJD4(8), KLF1(8), NANOG(8), LDHB(8), SASH1(8), PCDHB8(8), PLA2G12A(8), ANGPTL8(8), TMEM117(8), PTGR2(8), DOC2A(8), GATD3A(8), IER2(8), GRIK2(8), STEAP1(8), RAB37(8), RCE1(8), GLTPD2(8), FBF1(8), EGFL6(8), OLIG2(8), LILRA4(8), AC008750.7(8), PRKAR2B(8), PTPRU(8), PCDHB4(8), NXPE1(8), POLR3H(8), NIN(8), ITPK1(8), GDPD3(8), SLC17A7(8), RPS6KB1(8), EPM2A(8), PLA2G4A(8), FOXO3(8), RARRES1(8), RHOQ(8), DCAF10(8), BMP4(8), OTOR(8), ZNF780B(8), LRFN1(8), HOXD11(8), PDE6A(8), NEK3(8), BAAT(8), GPAT3(8), APP(8), SKP2(8), LUC7L2(8), AK3(8), SH2D6(8), MERTK(8), THY1(8), CPA5(8), UBR1(8), MYL3(8), C1orf115(8), KIAA0895(8), FOXK1(8), ANKS6(8), HEXD(8), TMED10(8), RHOD(8), GMPPB(8), LINC02873(8), C14orf177(8), TSPYL6(8), CITED4(8), OR8H3(8), NUTM2A(8), RBM11(8), TMEM179B(8), SRL(8), ZNF749(8), PDE2A(8), SERPINA13P(8), SUPT5H(8), ZSCAN16(8), HNRNPAB(8), MAP1LC3C(8), MPIG6B(8), TRIM40(8), MAGEA12(8), AC104389.5(8), STRIT1(8), ATP6V1G2-DDX39B(8), CHURC1(8), PTGES3L(8), NBPF14(8), GOLGA6L22(8), C11orf98(8), ZIC2(7), LAMC2(7), PITX1(7), SERTAD4(7), SH3BP2(7), UNC13D(7), SNX17(7), MTERF4(7), APOBEC2(7), ANAPC13(7), NDFIP1(7), PRPH(7), PTPRQ(7), GLRA1(7), CCZ1B(7), MIPOL1(7), AHCTF1(7), PLA2R1(7), LCN1(7), NLRP4(7), PGAP3(7), IL31RA(7), SUN3(7), BLCAP(7), KLHL26(7), C8orf74(7), KRT9(7), SLC25A30(7), AFMID(7), HTR3D(7), FAM180A(7), CPNE4(7), CR1(7), ZNF816-ZNF321P(7), PRH1(7), IFNA17(7), CCDC169-SOHLH2(7), AL024498.2(7), POLDIP2(7), MCUR1(7), CDH17(7), KIZ(7), DNAJB11(7), BRD1(7), CTSZ(7), DHX35(7), TTC23(7), ELL(7), RNF32(7), ACTR3C(7), PLGRKT(7), DNPH1(7), CCNG1(7), GNB4(7), IL1B(7), FOXA2(7), ZFP36(7), LRRC17(7), KL(7), PLAA(7), LRRC1(7), TLR2(7), PREB(7), HERC3(7), TTC6(7), BBS4(7), KIF2B(7), DYM(7), TIAM2(7), IGFBP1(7), AUH(7), GLUD1(7), SCGB1A1(7), C4orf33(7), ADGRA3(7), CYLC2(7), TMPRSS3(7), ALOX15(7), MON1A(7), ABCA1(7), FAM204A(7), ASPG(7), GOLM2(7), KLHL26(7), ARPP21(7), GRB2(7), C1orf105(7), RGPD6(7), AIDA(7), POLR3C(7), GAGE2A(7), DCAF8L2(7), PRIM1(7), SMOC1(7), HMGN2(7), MCCD1(7), PRR3(7), PNMA8B(7), PRR20A(7), OR51A2(7), SPDYE3(7), OR2A25(7), DHFR(7), DSCR9(7), PRAMEF11(7), C3orf85(7), AC069368.1(7), CD8B2(7), INMT-MINDY4(7), C8orf49(7), AC090527.2(7), ZNF561-AS1(7), ERVV-2(7), SSX4B(7), PRAMEF5(7), DOC2B(7), AGK(6), SCMH1(6), ST6GALNAC2(6), SPP2(6), NSF(6), CLUL1(6), CDC14B(6), SULT2B1(6), EPHX3(6), BCL7A(6), PDC(6), UBN1(6), PEX6(6), TBCC(6), PAICS(6), THAP10(6), PGPEP1(6), RIN2(6), C7orf26(6), SYTL5(6), SLC43A1(6), CDC42EP2(6), ZUP1(6), THEM4(6), CRYBA2(6), PF4(6), LOXHD1(6), PRELID1(6), KLF17(6), CCDC63(6), TOPAZ1(6), RRH(6), IFNL1(6), TM2D3(6), FAM174B(6), GSAP(6), AKAP14(6), TCEAL3(6), TSEN15(6), LTN1(6), PCDHA9(6), TM6SF2(6), POLR2M(6), AC100868.1(6), CCDC163(6), DYRK4(6), CPS1(6), RPL26L1(6), ELN(6), ATP11B(6), RASGRF1(6), KARS1(6), TIE1(6), KIF26A(6), TTC39A(6), TF(6), DAZL(6), TUBB1(6), MCTS2P(6), TNNT1(6), CD79A(6), DNAJB6(6), CLIP2(6), SLC6A12(6), RND3(6), HOXB3(6), TGM3(6), EIF3G(6), SHFL(6), SELENOS(6), PODNL1(6), RTN3(6), MYCN(6), ZNF670-ZNF695(6), FAM8A1(6), CGREF1(6), FGF2(6), CASQ1(6), C1orf35(6), AHSG(6), FAXC(6), SLC22A3(6), CCDC83(6), WNT3A(6), SAMD8(6), CIB4(6), CD3G(6), CYP11B1(6), TNFSF13(6), NOSTRIN(6), IGFBP7(6), ADORA1(6), ABHD6(6), SLC51A(6), IFI27(6), C1QL3(6), B4GALNT2(6), RNF214(6), RBFOX3(6), AQP2(6), HDGFL2(6), OR4K15(6), RAMAC(6), GPS1(6), MZB1(6), NUDCD2(6), JUNB(6), KRTAP4-4(6), OR8U1(6), FAM71D(6), GPR171(6), ZNF135(6), TGIF1(6), ZFPM1(6), MAF1(6), PUF60(6), SERTM1(6), TSPYL5(6), TIGIT(6), LRIT3(6), MAPK11(6), KANK3(6), TMCO2(6), CNR2(6), LINC00336(6), ARMH1(6), OXLD1(6), TMEM225(6), SPDYC(6), KRTAP27-1(6), STK38L(6), FMO9P(6), C2orf16(6), C5orf66(6), AC138647.1(6), CYP21A2(6), FAM90A20P(6), SMIM27(6), KRTAP5-8(6), AC244197.3(6), MRPL33(6), FER1L6-AS2(6), SMIM35(6), FNTB(6), LYPD8(6), TUBB8(6), AC104581.2(6), RHEX(6), NOTCH2NLA(6), AC008878.2(6), TEX13A(6), CT45A3(6), AC010326.2(6), C17orf50(6), PCDHB16(6), AL109827.1(6), OR51G1(6), STAB1(5), STMN4(5), ISL1(5), HPF1(5), CD200(5), FBXO7(5), HNF4A(5), CCL17(5), NFKBIB(5), PON3(5), HPS1(5), PRPF19(5), CHORDC1(5), LEPR(5), GDA(5), MOB3B(5), PMS2P5(5), LYPD3(5), INS-IGF2(5), THEMIS2(5), PIK3C2B(5), SNX14(5), SLC27A3(5), PKLR(5), INPP1(5), CCDC171(5), MBL2(5), QSOX2(5), BEX3(5), RAB26(5), ZNF747(5), ZNF354B(5), C8orf33(5), HOATZ(5), CHEK2(5), PRAME(5), ZFP91(5), FOXD4L3(5), HAPLN4(5), SERPINB2(5), LAYN(5), KRTAP5-10(5), SLC35F6(5), BBIP1(5), RNF148(5), ENSG00000274744(5), ARSD(5), PAFAH1B1(5), TBC1D23(5), TARBP1(5), YBX1(5), FGFR2(5), ATP12A(5), SULT2B1(5), STRN4(5), POU4F3(5), TYRO3(5), PSMC1(5), PPP4R3A(5), MMP15(5), ZC2HC1A(5), KIR3DX1(5), PTN(5), PRKAG2(5), PRKAR1A(5), PDC(5), IGSF21(5), APOL5(5), CPLANE2(5), CD101(5), TCN1(5), APC(5), EDNRB(5), CDK9(5), SEC24B(5), LGR5(5), PDX1(5), REM2(5), IGF1R(5), NLRC5(5), SRP9(5), GGPS1(5), ADAMTS1(5), PIEZO2(5), EPHB1(5), IL34(5), RADIL(5), VPS28(5), KASH5(5), PLCD3(5), GABRB1(5), FEV(5), SCRG1(5), CDC20B(5), LETM2(5), SMCO2(5), PPP1R14D(5), TAF10(5), MAPK7(5), DDIT4(5), APEX2(5), UBE2E1(5), CEL(5), HDAC3(5), KRCC1(5), RARG(5), FAM222B(5), FKBP2(5), ARL4D(5), MYPOP(5), EID2(5), PIDD1(5), IMPDH2(5), UCN3(5), OR52N5(5), C10orf120(5), SRPK3(5), IQCF2(5), TMEM210(5), TEX38(5), KRTAP17-1(5), TAF9B(5), TMSB4XP8(5), CLEC20A(5), C2orf80(5), KCTD21(5), RELN(5), IQANK1(5), SAP25(5), KRTAP9-6(5), TMEM238(5), RAMACL(5), UBE2L5(5), KCNQ1DN(5), THEGL(5), AC005726.1(5), OR4C13(5), GABRQ(5), PPIAL4H(5), Z84492.2(5), SEBOX(5), SRCIN1(5), H2AC17(5), OR51F1(5), DLX6(4), PGM3(4), HEBP2(4), NNAT(4), GPATCH1(4), THOC1(4), NUP50(4), RSPH6A(4), SHD(4), USP9Y(4), EVA1A(4), PRG4(4), ZP4(4), PPL(4), PPP4R4(4), TMTC4(4), SLURP1(4), SPINK2(4), COLGALT1(4), TMEM106C(4), TMEM14B(4), TSPAN3(4), FCGR3B(4), TTC7B(4), AKIP1(4), MMRN2(4), CST9(4), FBXO45(4), DENND6A(4), NPM1(4), BPIFC(4), CLDN6(4), TMPRSS12(4), PRR5(4), CMC1(4), CCDC151(4), MARCHF5(4), AGAP9(4), WEE2(4), ZNF880(4), XKR9(4), LY6G6E(4), ENSG00000228439(4), CFTR(4), CACNG3(4), AKAP11(4), GEMIN8(4), CTPS2(4), NPFFR2(4), NOTCH3(4), NUP37(4), BPIFB2(4), RABL2B(4), SLC4A4(4), AQP6(4), ERO1B(4), GNAS(4), CCDC80(4), TMEM14A(4), HSCB(4), PVALB(4), NELFCD(4), EEF1A2(4), MAGED2(4), CHRAC1(4), RASIP1(4), CYP3A5(4), NOBOX(4), COMMD9(4), UST(4), RPS12(4), XRN1(4), OTOF(4), CREB1(4), PPL(4), ACYP1(4), EIF2B2(4), TNFRSF8(4), GJB6(4), NPY(4), SMU1(4), RASSF8(4), MAGEA9(4), METTL8(4), ZNF391(4), MEA1(4), EEF1E1(4), MIF4GD(4), SRMS(4), DEFB126(4), VPREB3(4), TXNDC17(4), FAM155B(4), MTRES1(4), TXLNGY(4), GALNT15(4), TNS4(4), SNAP25(4), RIN2(4), SARAF(4), DPH6(4), ABCB10(4), DNAJB5(4), FLOT1(4), C6orf52(4), NDUFAF1(4), ANXA3(4), ETNK1(4), FAM181A(4), C17orf64(4), TRIM65(4), SMAD4(4), CERS2(4), RPS27A(4), RUBCN(4), MUC4(4), MTA2(4), ATPSCKMT(4), PLA2R1(4), CCNB2(4), SNX22(4), GATD3A(4), PKN3(4), SHANK2(4), TAF6L(4), EN1(4), BIRC8(4), ICOS(4), KIAA1143(4), C5orf63(4), OSGIN2(4), DCAF13(4), SLC16A9(4), LIPC(4), PRKCB(4), HSP90B1(4), BEX3(4), RHEBL1(4), ZNF610(4), ZSWIM1(4), GDNF(4), WFDC13(4), DNAJC21(4), PPIP5K1(4), RGPD8(4), YWHAG(4), CDH2(4), LRRC8E(4), OR10H3(4), NME6(4), MAB21L3(4), TNKS(4), DAB1(4), PPP1R14B(4), AGFG1(4), ZNF266(4), OR51B6(4), GATA2(4), ZBTB42(4), F2(4), FAM71C(4), PAK2(4), OR5AS1(4), OR6S1(4), C17orf77(4), PPP1R2(4), PABPC1L2B(4), FOXD4L4(4), AQP12B(4), SCN10A(4), AHNAK2(4), UBE2L3(4), DMWD(4), CHP1(4), COX8C(4), KRTDAP(4), VN1R2(4), RYR1(4), INCA1(4), ANXA4(4), SHISA4(4), H3C14(4), IFIT1B(4), TCEAL5(4), ZDHHC18(4), ZDBF2(4), HSPA1A(4), PRAMEF9(4), KRTAP5-11(4), MROH6(4), LGR4(4), ONECUT3(4), KRTAP4-11(4), TM6SF2(4), EML6(4), IQCF6(4), ZBED1(4), PRSS41(4), AATBC(4), FAM240C(4), KRTAP10-10(4), C19orf73(4), MKRN2OS(4), FRG2B(4), TEX22(4), H2BS1(4), APOC2(4), YAE1(4), KRTAP19-3(4), APOBEC3C(4), AL360181.3(4), AP001458.2(4), TEX49(4), AC022826.2(4), SCGB1C2(4), AC006486.1(4), FBXO17(4), CTAGE6(4), NUDT3(4), AC022400.5(4), FAM106A(4), NPHP3-ACAD11(4), SMIM34B(4), PMS1(3), OGFOD1(3), ZNF184(3), VSX1(3), ANAPC15(3), LDAH(3), PYROXD1(3), DPPA4(3), LRRC4B(3), NTPCR(3), DPT(3), LECT2(3), PIP4P2(3), TENT5B(3), SAP30BP(3), TPCN2(3), KNCN(3), CAPN13(3), TIGD6(3), FAM204A(3), FRAT1(3), LMO1(3), SPRR1A(3), MTX3(3), ZNF511(3), ZNF814(3), KRT81(3), OR52A4P(3), AL049697.1(3), H2AL1RP(3), CRYBB2(3), ARMS2(3), ST20-MTHFS(3), EML2-AS1(3), AL121758.1(3), FAM243B(3), PROM1(3), CEACAM7(3), RANBP9(3), PGM3(3), CHDH(3), ADSS2(3), OTC(3), CYFIP2(3), TRAF3IP2(3), CASP8(3), FAM107B(3), DHX29(3), GAL(3), ACAP1(3), RGS11(3), HOXA9(3), PKD2L2(3), THOC1(3), DDX1(3), KCNN2(3), ME2(3), NOA1(3), MTMR2(3), SLC9A1(3), WHRN(3), FKBP3(3), PTK6(3), TLDC2(3), VAPA(3), RBM3(3), ZDHHC15(3), GSPT1(3), CEP152(3), VPS18(3), GSR(3), NUCB1(3), KCNA7(3), NOVA2(3), GRWD1(3), ETV2(3), TFPI2(3), MRPL32(3), LHX2(3), CREB3(3), GLIS3(3), RAD51C(3), ENO3(3), UNC119(3), PTPMT1(3), LTA4H(3), MRPL2(3), CNOT6(3), NPRL2(3), CSPG5(3), PRDX6(3), SERP1(3), KIAA1191(3), PRXL2A(3), SLC25A16(3), MIR9-1HG(3), PRKCG(3), RNF6(3), GNAI1(3), KDR(3), YWHAH(3), NDUFA10(3), CALY(3), HBZ(3), YIPF2(3), MAP3K10(3), RHPN2(3), VPS13B(3), STARD13(3), LGALS12(3), ACTR3B(3), DDB2(3), LTV1(3), C7orf25(3), PPIL1(3), SLC37A4(3), SSB(3), ENPEP(3), FITM1(3), NLRP12(3), C1orf56(3), OAZ3(3), SLC27A3(3), NT5DC4(3), TM4SF19(3), SNCA(3), NHP2(3), WTAP(3), CLTRN(3), FATE1(3), CCDC25(3), PLPP5(3), ST8SIA6(3), TMEM218(3), KCTD14(3), GABRA2(3), PPP4R1(3), TIAM1(3), TMEM171(3), RER1(3), CNNM4(3), IGF2BP1(3), IER2(3), PGAP3(3), AQP5(3), TSACC(3), PLSCR2(3), ADCY1(3), OSR2(3), TSHR(3), TTC8(3), HSPA12A(3), C16orf78(3), TMEM130(3), GSDMA(3), FAM83B(3), IL12A(3), MUC17(3), OBP2B(3), PIK3CD(3), NINJ2(3), HOXB2(3), GCSAM(3), MIR7-3HG(3), PCDHB9(3), GRINA(3), GVQW3(3), CATSPERE(3), LYNX1(3), H2AW(3), SOX2(3), PRKAG1(3), CCDC125(3), KIAA2026(3), KCTD8(3), PRKX(3), PLA2G6(3), THAP7(3), LINC00839(3), TNFRSF4(3), CMC1(3), POTEG(3), COL14A1(3), GTF2IRD2(3), SRGAP1(3), S100A7L2(3), C14orf178(3), CYRIA(3), H2BC12(3), TUSC1(3), SPOUT1(3), SAMD13(3), FKBPL(3), CD300LD(3), MALRD1(3), ZBTB48(3), KRTAP4-8(3), SYCE1L(3), C2orf91(3), AMZ2P1(3), MBLAC1(3), C10orf105(3), C20orf202(3), OR2T7(3), SBK3(3), RPS27AP5(3), PATE3(3), MIR600HG(3), TNFRSF13B(3), KRTAP5-4(3), TICAM2(3), ADH1C(3), CCDC153(3), TUNAR(3), ALG1L2(3), CENPS-CORT(3), C1orf210(3), RHPN1-AS1(3), AC005324.3(3), OR8G5(3), NEDD8-MDP1(3), TRIL(3), AL139300.1(3), ZBED6(3), SCX(3), AC010547.4(3), GOLGA6L7(3), PPIAL4A(3), AC007998.2(3), H4C15(3), RBAKDN(3), AC117457.1(3), AL109811.3(3), IQCA1L(3), FP565260.6(3), CENPQ(2), MAGEC2(2), SEH1L(2), NECAP1(2), SMPX(2), CRYBB3(2), SIRPB1(2), CDADC1(2), VWA8(2), PIEZO1(2), CLUAP1(2), TMEM87A(2), SYNGR4(2), SUSD1(2), FRG1(2), IMPG1(2), RAB3GAP1(2), PADI2(2), RNF146(2), C19orf25(2), PROX2(2), ACYP1(2), SERP1(2), DNPEP(2), KCNS1(2), H2BC11(2), RNASE1(2), CRACR2A(2), SSBP4(2), CHIT1(2), CCDC59(2), CATSPERB(2), ANP32D(2), GALNT6(2), IL19(2), ACP4(2), DDIT4L(2), MAGEC1(2), DEDD(2), NKX6-3(2), ACSF2(2), DAPK3(2), KLK1(2), TTC39C(2), FNTA(2), CRCT1(2), ATP6V0E2(2), ZNF672(2), MACROD2(2), EGFL7(2), PHYHD1(2), PDE4DIP(2), ZDHHC20(2), FKRP(2), ZFP41(2), SRPRA(2), TAL2(2), CIDEC(2), MAGEH1(2), GFRAL(2), ZNF559(2), LYPD2(2), MAN1A2(2), PLPP6(2), ZNF580(2), ARHGAP19(2), GALT(2), AP5Z1(2), CCDC153(2), AP002748.5(2), AC015688.4(2), AC011479.1(2), H2AC4(2), ST7(2), AGK(2), REV3L(2), ABHD5(2), HEBP1(2), GPRC5A(2), MAMLD1(2), CD44(2), TFB1M(2), COL23A1(2), HPF1(2), ASB1(2), PPP2R5A(2), NFYC(2), CLDN18(2), PFKP(2), CACNB1(2), SIRT2(2), MAOB(2), FRMPD1(2), ATP2B1(2), TMEM38A(2), SELENOO(2), CA12(2), TUBE1(2), FGF4(2), RBM7(2), SPAG5(2), SIRT6(2), NEBL(2), GNB1(2), CLUL1(2), SMARCA2(2), MAGI3(2), COL19A1(2), COBLL1(2), ULK2(2), PDS5B(2), AK6(2), SEH1L(2), CEACAM6(2), AAMDC(2), CPXM1(2), ALKBH5(2), RGS17(2), MFSD11(2), MAGEB2(2), ZBED4(2), GSTZ1(2), RASSF2(2), BMX(2), OPN1LW(2), LYRM1(2), NME3(2), PIEZO1(2), CSK(2), HERC1(2), RAB2A(2), TUBB4A(2), DYRK1B(2), RABAC1(2), SIGLEC5(2), KCNN1(2), TMEM59L(2), ZNF85(2), ATRNL1(2), HPS1(2), SORCS1(2), AREG(2), SLC2A9(2), CHORDC1(2), FGF6(2), LPCAT3(2), TDP2(2), RBM24(2), SIM1(2), MED23(2), HECA(2), CUTA(2), HSPA9(2), SUB1(2), CPEB4(2), BCL6(2), MOB1A(2), WDR77(2), FBXO6(2), MIIP(2), WLS(2), PADI2(2), MESD(2), DDX59(2), UBN1(2), GLRXP3(2), ZC2HC1C(2), PCDHB8(2), TRMT1L(2), FLT3(2), PAEP(2), TAF1L(2), PHF24(2), GIPC1(2), SERPINB6(2), PCSK2(2), MAX(2), TMEM53(2), TSKS(2), TRAF2(2), RAC2(2), MRPS12(2), NEDD8(2), CHRNA10(2), ERMARD(2), PXDN(2), ZNF426(2), ACSS2(2), ENOSF1(2), LPIN3(2), TMCC2(2), RXFP2(2), CA1(2), MRO(2), IRAK2(2), SYT6(2), STK26(2), TIMM10(2), STT3A(2), FAM189A2(2), TMEM243(2), AVIL(2), RDH5(2), CCDC142(2), DCTN3(2), UQCC2(2), SECISBP2L(2), SHF(2), KIAA1109(2), NAAA(2), KIF21A(2), AEBP2(2), SLC38A4(2), LNX2(2), MORN3(2), MBD1(2), PFKL(2), PSMA5(2), ABL2(2), SMYD2(2), THSD7B(2), ECE2(2), GLRA1(2), ANO7(2), TBC1D32(2), RNF217(2), C7orf26(2), SLC12A9(2), CNPY1(2), CHRNB3(2), MIGA2(2), DCUN1D2(2), FREM2(2), FAM177A1(2), NDUFC2(2), JMY(2), ZNF547(2), PTPRK(2), SREK1IP1(2), C16orf74(2), NRGN(2), SAXO1(2), RWDD2B(2), GLYATL2(2), XKR8(2), ADIPOR1(2), C19orf47(2), TOR2A(2), ZER1(2), NEK8(2), CXCR5(2), UBE2Q1(2), ALKBH4(2), YDJC(2), ZG16B(2), SNX7(2), SLC30A7(2), SLC9C2(2), CNST(2), SLC16A14(2), ALPP(2), PMVK(2), PRKCI(2), GMPS(2), FANCD2OS(2), PF4(2), RHOBTB3(2), FASTK(2), TMEM67(2), VCP(2), PPP1R36(2), TRUB1(2), FAM227B(2), AKIP1(2), CCNDBP1(2), PIP5KL1(2), ZNF528(2), NLRC3(2), RNF187(2), COA6(2), TAP1(2), LRATD2(2), STXBP6(2), CENPX(2), SIMC1(2), NIPA1(2), CCDC144A(2), COX7B2(2), IRX2(2), PLA2G1B(2), PAQR8(2), TEX13B(2), HSFX1(2), SOCS5(2), ZNF561(2), VAT1L(2), IFNB1(2), OR10V1(2), PSME3IP1(2), TRMT112(2), NET1(2), AC013489.1(2), TNK1(2), MIR1-1HG-AS1(2), KLK15(2), SRP72(2), ODAPH(2), CA5A(2), DDIT3(2), SFN(2), HMGB4(2), PHLDB3(2), LRRC37A3(2), C8orf31(2), SPATA31E1(2), ZNF354B(2), DYNAP(2), ATOH7(2), KCTD4(2), DEFB119(2), GPR137C(2), ANKRD62(2), TP53TG1(2), CDY2A(2), WFDC10B(2), FANCF(2), RIMBP3C(2), OVCH2(2), CCDC159(2), ACSM5(2), LINC00518(2), ASCL2(2), LRTOMT(2), PGP(2), OLIG1(2), ACOT1(2), FOXD4L1(2), SATL1(2), MROH2A(2), C6orf120(2), NUPR2(2), HS6ST3(2), PRAME(2), PIGP(2), CYP2R1(2), CENATAC(2), LCE5A(2), BACE1(2), TMEM17(2), VSTM2B(2), FOXD3(2), EZHIP(2), SSX7(2), RINL(2), DAZ1(2), SLC38A3(2), ZP3(2), INSC(2), CCDC9B(2), OR2G6(2), POTEA(2), AC099489.1(2), FAM111B(2), ZNF565(2), TCEAL3(2), PLXNB2(2), CTBP1-DT(2), GALP(2), GPAA1(2), NBEAP2(2), ZNF121(2), ZBTB14(2), MAN1A2(2), PHETA1(2), OGA(2), ZNF511(2), GPATCH3(2), EGFL6(2), DCAF12(2), DCLRE1A(2), PJA2(2), CHML(2), EEF1AKMT2(2), DPPA5(2), CXorf66(2), BTNL2(2), AGPAT1(2), DEFB121(2), SPATA31A1(2), TRIM13(2), SLCO1B7(2), IGLL3P(2), FOXL2NB(2), DIO1(2), SIPA1(2), TMX2(2), DDX47(2), SLC6A10P(2), PEX26(2), BCORP1(2), FAM72D(2), KRTAP1-5(2), MYBPHL(2), OR2A2(2), ORM2(2), HSBP1(2), FAM133B(2), C11orf94(2), RPEL1(2), LINC00479(2), SHISA9(2), ETDA(2), ALKBH6(2), PEDS1(2), CORT(2), PWP2(2), ARPIN(2), SMIM34A(2), GPR162(2), USP17L20(2), PRB1(2), UTP14C(2), SAA2-SAA4(2), LY6G6E(2), MTRNR2L9(2), PRECSIT(2), CLLU1(2), CNPY2(2), CLEC5A(2), AC009779.3(2), SERPINA2(2), SLC35G6(2), BUB1B-PAK6(2), AC087632.2(2), SMIM28(2), SRSF8(2), DYNLL2(2), AC015813.2(2), AC008770.2(2), EML2-AS1(2), AC003005.1(2), AC011530.1(2), AC011452.1(2), AC008750.7(2), AC011473.4(2), RPS10-NUDT3(2), CCL5(2), GTF2H5(2), KMT2B(2), ZBTB8B(2), AC017083.3(2), TPTE(2), CCL23(2), PRAMEF27(2), LENG9(2), ZNF516-DT(2), SIK1B(2), AC036214.3(2), H2AC16(2), GOLGA6L6(2), RPS4Y2(2), ENSG00000204683(1), ENSG00000183791(1), ENSG00000184258(1), DBNDD1(1), ABCB5(1), MPO(1), MAP3K9(1), ADIPOR2(1), CAMK1G(1), MPND(1), IL32(1), TENM1(1), NME1-NME2(1), BRCA1(1), UBR7(1), PSMC4(1), DNASE1L1(1), SLC38A5(1), ATP1A2(1), HGF(1), PLEKHB1(1), NLRP2(1), SNAPC1(1), CCDC28A(1), HSD17B6(1), VIM(1), KCNG1(1), BTN3A1(1), CENPQ(1), ARID4A(1), PNPLA6(1), GAB2(1), TRIO(1), MTREX(1), C2orf83(1), ADAM28(1), EPHA3(1), GPM6B(1), POLR2B(1), THOC3(1), SYNE2(1), PUM2(1), PARP12(1), GNA15(1), MPC1(1), DLX3(1), SPA17(1), NGFR(1), AP3D1(1), ZNF76(1), GNAI3(1), GOLGA5(1), ZFY(1), ATP2B3(1), ROCK1(1), ATP11A(1), POLR1A(1), ST6GALNAC1(1), SIDT1(1), PANX2(1), PTGS2(1), NSF(1), TEAD2(1), EIF4G3(1), TTC38(1), PAX2(1), GPATCH1(1), ARHGEF1(1), DNAJC10(1), ACTN2(1), LAMP3(1), ACER3(1), TIGAR(1), CDC14A(1), DNM2(1), STX7(1), EPHA6(1), MEF2C(1), DUSP12(1), PHLPP1(1), PGR(1), KCNK2(1), KAT6A(1), ZNF586(1), PPIE(1), APLP2(1), RAB10(1), CAD(1), OVGP1(1), PPEF1(1), UIMC1(1), LPCAT2(1), KIF9(1), F11(1), TASP1(1), NOS1(1), OSBPL8(1), CDV3(1), UNC13D(1), FMO2(1), MRPS18A(1), IFT74(1), CATSPERG(1), TECR(1), MADCAM1(1), P2RX6(1), BCL2L13(1), SUSD2(1), HIRA(1), Z83844.1(1), SRRD(1), CABP7(1), GZMB(1), PYGL(1), DAAM1(1), BDKRB1(1), RPS6KA5(1), YY1(1), PABPN1(1), MMP9(1), ANGPT4(1), SIRPB1(1), MANBAL(1), CHMP4B(1), ACTR5(1), CELF4(1), RBFA(1), USP14(1), LIPG(1), EMD(1), TAZ(1), SMS(1), VWA8(1), VPS35L(1), KNOP1(1), TMEM87A(1), ZNF106(1), TRIM35(1), STK3(1), AKAP8(1), CCNP(1), SHD(1), SYNGR4(1), SLC5A5(1), ATP4A(1), SMG9(1), FBXO24(1), AGR2(1), GLI3(1), RHEB(1), MYL7(1), SUSD1(1), CDC37L1(1), KCNT1(1), CA9(1), UBE2R2(1), DNTT(1), PKD2L1(1), SH3PXD2A(1), GLRX3(1), FBXL20(1), BLMH(1), FOXN1(1), OCIAD1(1), UCP1(1), FBXW7(1), DCPS(1), PPP6R3(1), TMEM109(1), APOA4(1), EIF4G2(1), SLC11A2(1), MYF5(1), ITFG2(1), MYL2(1), SLC38A1(1), SPRING1(1), C2CD5(1), RAB35(1), AL021546.1(1), FGFR1OP2(1), KLRB1(1), MAK(1), SMIM8(1), CEP85L(1), GPR63(1), B3GAT2(1), GMNN(1), SRF(1), PCDHB6(1), ARRDC3(1), PRLR(1), RARS1(1), ERGIC1(1), ACTR8(1), ARL6(1), UBE3A(1), WNT5A(1), PRKAR2A(1), ACAP2(1), TUSC2(1), EIF1B(1), TNNC1(1), SNX17(1), EVA1A(1), PAPOLG(1), NEU2(1), TXNDC9(1), PLCD4(1), CHMP3(1), PASK(1), TAF1B(1), ATF2(1), PARK7(1), AGMAT(1), TNNI3K(1), ARTN(1), PRDX1(1), IRF6(1), RPA2(1), STK11(1), SPCS2(1), OLFM3(1), TRPM6(1), CCDC92(1), PPP4R4(1), TECTB(1), SMNDC1(1), MOB3B(1), MTHFD1L(1), IQSEC3(1), TAS2R8(1), BCL2L14(1), TAS2R9(1), CSTA(1), DPPA4(1), ZMYM2(1), ZCCHC17(1), CXCR4(1), OBP2A(1), LY9(1), OCM(1), WIPF3(1), FKBP9(1), DDX39A(1), EEF1AKMT3(1), NDUFAF4(1), PFKFB2(1), PMS2P5(1), SNX21(1), KCNS1(1), STX16(1), MAGEA10(1), BTN2A2(1), PEX6(1), NQO2(1), H2BC11(1), OR2B6(1), KLHDC3(1), KLHL31(1), GOT2(1), PLGLB2(1), IL37(1), POLR1B(1), STK35(1), AP5S1(1), FAM110A(1), ARMCX5(1), SLURP1(1), EMG1(1), NXF5(1), OR7A10(1), SYNGR3(1), AAMP(1), PAICS(1), ATF4(1), SPECC1(1), PODXL(1), DNAJB9(1), NDUFA5(1), FEZF1(1), OPN1SW(1), CHN1(1), OSGEPL1(1), HOXD13(1), PSMG2(1), TMOD2(1), THAP10(1), ANAPC13(1), ATP1B2(1), CRACR2A(1), ANGPTL8(1), FAM98C(1), SAFB2(1), MAP1S(1), PGPEP1(1), SAMD10(1), PAK4(1), CHMP2A(1), SMPDL3B(1), HABP4(1), LATS1(1), AAR2(1), NDFIP1(1), DNAJB1(1), ZSWIM4(1), MATN2(1), ERAL1(1), BHMT2(1), CNDP2(1), ZDHHC8P1(1), ADCK2(1), CCDC59(1), LAMTOR5(1), AP4B1(1), FKBP11(1), CRB1(1), PRH2(1), ACP2(1), AGTPBP1(1), TES(1), ATP5MC2(1), PRPH(1), REPS1(1), LAMC1(1), WASHC4(1), VPS36(1), SUCLA2(1), CHST12(1), RSAD1(1), TRA2B(1), TANK(1), BLK(1), EPRS1(1), UBAP2(1), PIM1(1), KIAA0319(1), CLPS(1), MMP27(1), PAQR5(1), ARHGAP29(1), SLC44A5(1), IFT172(1), SIX3(1), CCDC54(1), PLCZ1(1), CD27(1), PEX5(1), NABP2(1), BRCA2(1), GALNT6(1), MDGA2(1), PTGR2(1), ZSCAN29(1), GCNT3(1), LINS1(1), CELF6(1), MARVELD3(1), CMTM2(1), SCRN2(1), MISP3(1), FEM1A(1), HUNK(1), RNPEPL1(1), CAPN10(1), PADI3(1), DMRTA2(1), SYPL2(1), ADCY10(1), DUSP10(1), JTB(1), FLG(1), SCCPDH(1), GUK1(1), OSR1(1), PDIA6(1), ABHD1(1), TPRKB(1), SLC4A10(1), CDCA7(1), FANCD2(1), STK11IP(1), SHQ1(1), ARL6IP5(1), AC073896.1(1), ALDH1L1(1), LPP(1), CCDC39(1), SLC10A6(1), ANK2(1), MARCHF6(1), SRD5A1(1), IQGAP2(1), SPATA9(1), BOD1(1), IRAK1BP1(1), SHPRH(1), CREB5(1), CASK(1), HDAC8(1), RAB41(1), GPR119(1), CSGALNACT1(1), SNX30(1), CRB2(1), GBGT1(1), SURF6(1), CIZ1(1), LRSAM1(1), POLR3A(1), PAOX(1), PAMR1(1), DGKZ(1), NCAM1(1), HTR3B(1), ATM(1), GLB1L2(1), OOSP2(1), C20orf144(1), SOGA1(1), CDC42EP2(1), KLRF1(1), TIRAP(1), KIAA1328(1), ADRA2A(1), TIMM8B(1), MIPOL1(1), EPS8(1), AKR1C2(1), SACS(1), BAG3(1), HAUS1(1), G6PC2(1), RPP38(1), ZNF837(1), IFIT5(1), MARVELD2(1), NRSN1(1), UBP1(1), CD8A(1), ASB17(1), ROBO3(1), ASZ1(1), MRPL39(1), RBM45(1), GPR61(1), ALX3(1), NAA11(1), BACH1(1), CLDN17(1), TSPAN7(1), GDF6(1), PTDSS1(1), HK1(1), FRRS1(1), EIF4A2(1), SST(1), LYZL4(1), ODR4(1), SUSD3(1), KCNJ15(1), PEX10(1), SSX8P(1), AGAP1(1), CLSTN2(1), FAM86C1P(1), EDA(1), MPZ(1), IFNAR2(1), ZBTB8A(1), ST6GALNAC6(1), VPS11(1), FDPS(1), FGFR4(1), BDH1(1), ACOX1(1), SRSF2(1), KLHL10(1), IP6K3(1), RPS6KA4(1), DHRS3(1), FAAP20(1), TM2D1(1), KLHDC8A(1), LRATD1(1), ZSWIM2(1), PDCL2(1), RNF25(1), FABP1(1), SYNPR(1), RYK(1), SLC4A1AP(1), NMNAT3(1), SFMBT1(1), HPGD(1), C4orf45(1), PRRC1(1), ERAP1(1), LINC01600(1), SLC35A1(1), STXBP5(1), IL31RA(1), GALNT10(1), KIF6(1), STEAP1(1), MIOS(1), SPIDR(1), INTS8(1), CCDC171(1), KIAA1958(1), TRMT10B(1), MELK(1), INTS6L(1), SUGT1(1), ZCCHC24(1), SOHLH1(1), GHITM(1), CLEC1B(1), C12orf50(1), OTOGL(1), TC2N(1), SERPINA12(1), AVPR1A(1), SCN3B(1), CYB5R2(1), RIC3(1), LMO1(1), TMEM41B(1), TMX3(1), NDST2(1), SLC38A8(1), IQCD(1), BLCAP(1), TMPRSS5(1), CATSPER2(1), NAV2(1), ANKDD1A(1), PLK1(1), MS4A7(1), DIS3L(1), CCDC178(1), PDIA3(1), FAM102A(1), CERCAM(1), ART5(1), TUBA1A(1), LY6D(1), ACER1(1), OTUB1(1), TMEM88(1), TMEM68(1), PAFAH1B2(1), KCNV2(1), MLKL(1), STAT3(1), LINC01620(1), FAM178B(1), GCSAML(1), CA5B(1), STK32A(1), DTWD2(1), BNC1(1), DUS1L(1), ZNF32(1), PRY(1), S100G(1), HSFY2(1), ZNF747(1), TIGD4(1), NANP(1), EMX2(1), RALGAPB(1), SLC26A5(1), OR8B12(1), NAIF1(1), TMEM126B(1), KRT9(1), PDE7B(1), SPACA5B(1), MROH2B(1), COL24A1(1), RAB4B-EGLN2(1), ANO5(1), CAMTA1(1), SPATA5L1(1), SYCE1(1), COL8A2(1), OR4C11(1), MBOAT1(1), BPGM(1), GNB2(1), ZNF738(1), MS4A10(1), CBWD1(1), RAB37(1), ADCY5(1), LIPM(1), MAP3K11(1), TRIB1(1), CST9(1), SUSD5(1), TOMM20(1), CHRNA9(1), C12orf76(1), ZCCHC12(1), TTC9B(1), TMEM81(1), GOLT1A(1), BRMS1(1), KCTD13(1), OR4S2(1), PARL(1), CHRNA7(1), LIPT2(1), CABP4(1), CTDNEP1(1), TSPEAR(1), A2M(1), RIMS2(1), KCMF1(1), VPS37D(1), MUC20(1), LY6H(1), FIBIN(1), ZBTB34(1), NUDT4B(1), KCNA3(1), CD19(1), PDE4DIP(1), AQP11(1), SHISA3(1), LINC00314(1), TUBAL3(1), OR13D1(1), C9orf50(1), HES7(1), RAD23A(1), ZBTB18(1), SHARPIN(1), GPHB5(1), APOBEC3B(1), TIGD5(1), BBS10(1), SSC5D(1), TH(1), OR2A4(1), ZDHHC20(1), METTL23(1), CCL13(1), OR8D4(1), RFX7(1), MGAT4C(1), UBE2E2(1), PGBD4(1), TEX19(1), CAPN12(1), MXRA7(1), PAPPA(1), NGRN(1), C12orf60(1), SLC25A10(1), NKX2-5(1), PTGDR2(1), GABRR3(1), WT1-AS(1), FAM9A(1), SYNDIG1L(1), GTF2H2C(1), ASB7(1), PI4KAP2(1), TENT5C(1), PSMG1(1), SETD3(1), TP53TG3(1), RP1L1(1), FAM162B(1), KCNH8(1), NPW(1), NPB(1), GOLGA6L4(1), IRAK1(1), TM2D3(1), BEX5(1), SERINC4(1), TCTE3(1), AQP12A(1), MANEAL(1), ANO9(1), LRRC37B(1), PGBD2(1), RGPD2(1), TARS3(1), LINC00158(1), SPATA45(1), MRPL40(1), NDUFA4L2(1), CLDN24(1), TRIM69(1), BICD2(1), PLK5(1), DLEU7(1), HTR3D(1), BPIFB4(1), EDARADD(1), CYP4F12(1), NAP1L3(1), GOLGA8R(1), NAP1L2(1), KATNA1(1), FSD2(1), KRT16(1), ZDHHC17(1), KRTAP23-1(1), CYP4A11(1), SLIT1(1), KRTAP12-1(1), ZNF546(1), C11orf96(1), HSPA14(1), MAGEH1(1), HAPLN4(1), ERC2(1), SLC18A3(1), C9orf153(1), FAM122A(1), C17orf99(1), ARL4C(1), TREML4(1), TUBB4B(1), CLEC2A(1), BLOC1S5(1), DUSP28(1), FSIP2(1), SBSN(1), FAM25G(1), PRSS48(1), IL1RAPL2(1), RASSF10(1), ZNF79(1), SEMA4A(1), KRTAP5-3(1), ZNF107(1), ZBTB44(1), SRGAP2B(1), NPIPB15(1), XRCC2(1), MRTFA(1), AMZ2(1), VKORC1L1(1), TEX43(1), METTL9(1), ZNF257(1), FAM110D(1), GSTK1(1), ZNF665(1), GZMM(1), ENTPD6(1), CPLANE1(1), CCER1(1), SLC22A24(1), NKIRAS1(1), SLC22A6(1), NPIPB13(1), OR2T6(1), RPS6KL1(1), AFDN-DT(1), HYLS1(1), TMEM207(1), ZNF69(1), AKR1C4(1), ABCA4(1), SFT2D1(1), TOX(1), CCDC152(1), TYW1(1), RASGEF1A(1), ZFP2(1), SOWAHA(1), COX20(1), RIPPLY2(1), C10orf62(1), ZYG11A(1), PBX2(1), PRRT1(1), LAYN(1), PPP1R11(1), HCG9(1), ZFP57(1), ASPDH(1), CBY3(1), IGFL4(1), CD177(1), PSG5(1), PCDHA9(1), PCDHA8(1), PCDHA2(1), ERICH4(1), SDHAF1(1), FABP9(1), LCMT1(1), NANOGNB(1), KRTAP5-1(1), SMIM21(1), COL6A6(1), CD200R1L(1), ARHGEF35(1), TTLL13P(1), C8orf82(1), NAXD(1), FOXI3(1), SOGA3(1), LCNL1(1), HNRNPUL2(1), MTCP1(1), NPIPA8(1), PHB2(1), GAGE10(1), FNIP1(1), TAS2R41(1), XKR9(1), TMEM14EP(1), CYTOR(1), ZNF812P(1), APOC4-APOC2(1), TMEM233(1), C5orf67(1), USP17L7(1), TAS2R46(1), SPINK8(1), PRB4(1), LINC00326(1), LINC00852(1), PPP1R2B(1), MTRNR2L4(1), ASCL5(1), IFNA13(1), UQCRHL(1), CTAGE9(1), LILRA4(1), ZNF542P(1), AL035460.1(1), MDFIC2(1), GNG10(1), INGX(1), KRTAP10-11(1), TTC4(1), TMEM35B(1), DBNDD2(1), TNFSF12-TNFSF13(1), ATP5MGL(1), CCDC169-SOHLH2(1), NT5C1B-RDH14(1), MSANTD3-TMEFF1(1), DCANP1(1), KBTBD11-OT1(1), ETV3L(1), LYN(1), ARMS2(1), CARD17(1), POLR2M(1), AC018523.2(1), AL357673.1(1), LIMS4(1), AC022335.1(1), RPL36A-HNRNPH2(1), C17orf49(1), TRIM6-TRIM34(1), OR11H7(1), AL096870.1(1), AL136295.5(1), AC093525.1(1), AC009163.3(1), SPDYE6(1), AC020636.2(1), AL049634.2(1), GOLGA8T(1), PPIAL4C(1), ANXA8L1(1), IGBP1P2(1), AC067968.1(1), AC010327.2(1), AC011511.4(1), AC091551.1(1), AC011479.1(1), AC007192.1(1), MAGIX(1), AC008758.6(1), ARHGAP19-SLIT1(1), AL365273.2(1), MTRNR2L11(1), MTRNR2L13(1), AC114490.2(1), Z84492.1(1), AL359736.1(1), C1QTNF3-AMACR(1), TBC1D3(1), H2AC12(1), MLLT6(1), ORAI1(1), AC008073.3(1), UBE2NL(1), TYW1B(1), ZNF670(1), PNMA8C(1), PRICKLE4(1), NPAP1L(1), H4C1(1), OR2S2(1), OR8D2(1), OR2T11(1), AC068946.1(1), CCDC163(1), AL512506.3(1)

5.4 Best C-index test in all runs

Best Elastic Net model (C-Index test)

[INFO] Coefs. list

[1] “ENSG00000007341, ENSG00000013392, ENSG00000064270, ENSG00000066735, ENSG00000075234, ENSG00000086061, ENSG00000091656, ENSG00000100994, ENSG00000102245, ENSG00000105176, ENSG00000106628, ENSG00000109103, ENSG00000110011, ENSG00000112304, ENSG00000112499, ENSG00000112584, ENSG00000112812, ENSG00000114771, ENSG00000116106, ENSG00000120159, ENSG00000120289, ENSG00000122692, ENSG00000125746, ENSG00000126353, ENSG00000129951, ENSG00000130538, ENSG00000130962, ENSG00000131203, ENSG00000133067, ENSG00000133800, ENSG00000134014, ENSG00000139687, ENSG00000142619, ENSG00000143549, ENSG00000144339, ENSG00000145040, ENSG00000145428, ENSG00000148357, ENSG00000148702, ENSG00000150750, ENSG00000151012, ENSG00000151640, ENSG00000151876, ENSG00000152467, ENSG00000153714, ENSG00000160202, ENSG00000162892, ENSG00000163453, ENSG00000164089, ENSG00000167165, ENSG00000167419, ENSG00000168824, ENSG00000168903, ENSG00000169248, ENSG00000169717, ENSG00000170054, ENSG00000170315, ENSG00000170423, ENSG00000171053, ENSG00000171054, ENSG00000171501, ENSG00000174944, ENSG00000179869, ENSG00000180347, ENSG00000180447, ENSG00000180871, ENSG00000181617, ENSG00000181698, ENSG00000181761, ENSG00000184434, ENSG00000185739, ENSG00000185823, ENSG00000186119, ENSG00000188897, ENSG00000188937, ENSG00000196092, ENSG00000196131, ENSG00000196666, ENSG00000196844, ENSG00000196860, ENSG00000197013, ENSG00000197406, ENSG00000203952, ENSG00000204539, ENSG00000204710, ENSG00000205111, ENSG00000213886, ENSG00000213931, ENSG00000214518, ENSG00000214642, ENSG00000222036, ENSG00000225396, ENSG00000230453, ENSG00000233932, ENSG00000235706, ENSG00000237353, ENSG00000237524, ENSG00000241106, ENSG00000241258, ENSG00000244234, ENSG00000248385, ENSG00000253731, ENSG00000254466, ENSG00000255307, ENSG00000255508, ENSG00000256269, ENSG00000275395, ENSG00000277288, ENSG00000278139, ENSG00000279073, ENSG00000281613”

Test set

Full set

Best Hub model (C-Index test)

[INFO] Coefs. list

[1] “ABCC2, AC005726.1, ACLY, ACTL10, ACTR10, ACTRT2, AGFG1, AKT1, AKT2, AKT3, ALB, APOE, ARL14, ATP1A3, BCL2, CALM1, CD40LG, CDC42, CDK4, CDKN1B, DDX41, DECR1, DYRK1B, EGFR, ELAVL1, ELP3, EPHA4, EPHA7, EPHB2, ERBB2, FBL, GART, GATA5, GFI1B, HDAC1, HERC1, HSPA1L, HSPA8, IL2, INS, INSRR, LCK, LGR6, LRRC19, MAP3K7, MAPK1, MAPK14, MAPK15, MAPK3, MAPK4, MAPK6, MAPK8, MATK, MYB, MYC, MYLK4, NFKB1, NRAS, NYX, OASL, OR4D10, OR4F17, PAX5, PCSK7, PI3, PIK3CG, PPEF2, PPP3CA, PPP3CB, PPP5D1, PRDM10, PRKAG1, PRKCH, PRKG2, PTEN, RAB11A, RAC1, RAD23B, RAD51, RAD51D, RALA, RAP1A, RASD1, RASL10A, RB1, RGPD1, RHOA, RHOC, RHOJ, RHOU, RIPK4, RPS6KA2, RXFP1, STAT1, STK3, TBP, TEC, TFRC, TK2, TNS1, TP53, TPM3, TTC28, UBB, UBC, UBD, UBL4A, UBL4B, UMPS, YWHAZ, ZNF429”

Test set

Full set

Best Orphan model (C-Index test)

[INFO] Coefs. list

[1] “AADAC, AC005832.4, AC011452.1, AC099489.1, AL365214.2, AL807752.6, AP003419.1, BTN3A3, BTNL3, C10orf120, C11orf53, C17orf67, C2orf74, CAAP1, CCDC160, CCDC189, CDSN, CRCP, CRYAA, CTAGE6, CTXN2, DEFB113, DICER1-AS1, DIO3, EDDM3A, EML2, ERVV-2, ETNPPL, FAM120B, FAM180B, FAM236D, FBXO16, FBXO4, FCGBP, FCRL3, FDCSP, FP565260.2, GBP5, GLYATL1B, GMCL2, HABP2, HLA-DOB, IDO1, IFNA7, IFT74, IL24, INMT-MINDY4, INSL5, ITPRID1, KIAA0100, KRT78, KRTAP2-2, LILRA2, LINC00337, LINC02860, LINC02881, LRRC27, LURAP1L, LYPD6, MAGEB4, MAP3K13, MROH2B, NPAP1, NSG1, NUGGC, NUTM2F, OR11H1, OR2I1P, OR2J3, OR2W1, OR5D18, OR5T1, OSTCP1, P3R3URF-PIK3R3, PATE1, PATE2, PATE4, PCDHGA6, PCSK6, PLPPR3, POTEM, PPM1G, PRR36, PRRG1, PRSS16, RAB34, RNF175, RPS4Y2, RWDD2A, SAYSD1, SIGLECL1, SLC25A47, SMIM10, SMR3A, SPDYC, ST7L, STAC2, SYT14, TARM1, TEX51, TMEM254, TNFAIP8L3, TOMM20L, TRIM75P, TRIM77, TTC38, TXLNGY, UCN2, UNC119, URI1, USP17L8, VN1R2, WFDC12, WFDC8, ZFHX4”

Test set

Full set

5.5 Best Log-rank test in all runs

Best Elastic net (Log-rank test)

[INFO] Coefs. list

[1] “ENSG00000007341, ENSG00000024862, ENSG00000038295, ENSG00000062582, ENSG00000064547, ENSG00000065371, ENSG00000087237, ENSG00000099338, ENSG00000100336, ENSG00000100994, ENSG00000102245, ENSG00000105409, ENSG00000106628, ENSG00000106809, ENSG00000108187, ENSG00000109511, ENSG00000110011, ENSG00000110243, ENSG00000112077, ENSG00000112146, ENSG00000112304, ENSG00000112499, ENSG00000112584, ENSG00000113924, ENSG00000114771, ENSG00000116106, ENSG00000117215, ENSG00000118496, ENSG00000120159, ENSG00000120289, ENSG00000121871, ENSG00000122783, ENSG00000124102, ENSG00000125878, ENSG00000126432, ENSG00000128683, ENSG00000130538, ENSG00000130540, ENSG00000132185, ENSG00000133800, ENSG00000133958, ENSG00000136457, ENSG00000141434, ENSG00000141738, ENSG00000141750, ENSG00000144036, ENSG00000144043, ENSG00000145040, ENSG00000145949, ENSG00000146707, ENSG00000147509, ENSG00000148357, ENSG00000148702, ENSG00000151067, ENSG00000154856, ENSG00000156234, ENSG00000160202, ENSG00000160882, ENSG00000164089, ENSG00000164175, ENSG00000166105, ENSG00000167772, ENSG00000168781, ENSG00000168903, ENSG00000169248, ENSG00000169717, ENSG00000170054, ENSG00000170315, ENSG00000170423, ENSG00000171501, ENSG00000172183, ENSG00000172519, ENSG00000174448, ENSG00000174914, ENSG00000174944, ENSG00000176695, ENSG00000176912, ENSG00000176928, ENSG00000178645, ENSG00000180822, ENSG00000182271, ENSG00000182512, ENSG00000183578, ENSG00000183785, ENSG00000184434, ENSG00000184785, ENSG00000185385, ENSG00000186265, ENSG00000186453, ENSG00000188937, ENSG00000197013, ENSG00000197165, ENSG00000197261, ENSG00000198598, ENSG00000198758, ENSG00000204539, ENSG00000213578, ENSG00000213886, ENSG00000225396, ENSG00000230453, ENSG00000230510, ENSG00000231274, ENSG00000233932, ENSG00000234469, ENSG00000237353, ENSG00000237524, ENSG00000242779, ENSG00000243775, ENSG00000244234, ENSG00000248385, ENSG00000250374, ENSG00000254959, ENSG00000255508, ENSG00000255526, ENSG00000259753, ENSG00000271321, ENSG00000274897, ENSG00000275395, ENSG00000276612, ENSG00000281613”

Test set

Full set

Best Hub model (Log-rank test)

[INFO] Coefs. list

[1] “ACTRT2, AKT1, AKT2, ALB, CDC42, CDK4, CDK5, EPHA4, HDAC1, HRAS, HSP90AB1, IL2, ISG15, JUN, MAPK8, MATK, NFKB1, NRAS, OASL, POTEE, RALA, RIPK4, RPS6KA2, SRC, TP53, TSPO, UBB, UBC, UBD, UBL4A”

Test set

Full set

Best Orphan model (Log-rank test)

[INFO] Coefs. list

[1] “AL365214.2, BFSP1, BTLA, C10orf53, CAAP1, CDSN, CLPSL2, COA8, CXorf65, DEFB113, ETNPPL, FCGBP, FDCSP, HLA-DOB, LINC01619, OR2A42, OR2I1P, OR2W1, P3R3URF-PIK3R3, PCSK6, POTEM, RNF175, RWDD2A, SLC39A5, ST7L, STAC2, SYT14, TARM1, TMEM254, TYMSOS, WFDC12, ZFHX4, ZNF702P”

Test set

Full set

NULL

6 Parameters for the report

## [INFO]          balanced.sets: TRUE
## [INFO]        calc.params.old: FALSE
## [INFO]           coding.genes: TRUE
## [INFO]     degree.correlation: pearson
## [INFO]          degree.cutoff:       0.000
## [INFO]            degree.type: string
## [INFO]      degree.unweighted: TRUE
## [INFO]      handle.duplicates: keep_first
## [INFO]                   log2: TRUE
## [INFO]                n.cores:      14.000
## [INFO]          normalization: center
## [INFO]                 ntimes:    5000.000
## [INFO]                project: ov.data.2018.11.30
## [INFO]                   seed:    1985.000
## [INFO]                 subset: Inf
## [INFO]   subtract.surv.column: (I do not know how to display this)
## [INFO]            target.vars: list(alpha = 0.2, vars = 30), list(alpha = 0.2, vars = 55), list(alpha = 0.2, vars = 110)
## [INFO]                 tissue: primary.solid.tumor
## [INFO]                  train:       0.800